Pharmacology, Biology, and Clinical Applications of Androgens. Current Status and Future Prospects

  • ID: 2174441
  • Book
  • 544 Pages
  • John Wiley and Sons Ltd
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Pharmacology, Biology, and Clinical Applications of Androgens Current Status and Future Prospects

Edited by Shalender Bhasin, Henry L. Gabelnick, Jeffrey M. Spieler, Ronald S. Swerdloff, Christina Wang, and Chuck Kelly

As agents that affect the male primary and accessory sex organs, androgens particularly the hormones testosterone and androsterone play a critical role in the development, functionality, and overall health of the male reproductive system. However, since androgens also have far–ranging effects on metabolism, neurological activity, and behavior, scientists exploring the contraceptive or therapeutic potential of androgens need reliable, up–to–date information on the complex biological activities of these agents.

Pharmacology, Biology, and Clinical Applications of Androgens: Current Status and Future Prospects presents contributions from leading investigators around the world, offering a focused, state–of–the–art summary of the central issues and controversies in androgen research. The book is arranged into sections covering androgen physiology, androgens and the prostate, and the neurobehavioral and metabolic effects of androgens as well as their role in disease therapy and male contraception, and the various delivery systems for each application. Every chapter in the text provides an expert opinion on a cutting–edge topic in the field while highlighting the key points of dissent and disagreement within the scientific community. This approach is intended to foster a deeper understanding of the status of androgen research and lay the groundwork for future investigations in each area.

This book explores such current topics as:

  • Androgen regulation of Sertoli cell function
  • Testosterone and spermatogenesis
  • Androgen effects on benign prostatic hyperplasia (BPH) and prostate cancer
  • Androgen effects on cognitive processes, sexual function, and aggressive behavior
  • Contraceptive efficacy of hormonal suppression of spermatogenesis
  • The latest transdermal and implantation delivery systems for androgens

Offering multifaceted coverage of the field, Pharmacology, Biology, and Clinical Applications of Androgens is an indispensable aid to all basic scientists and clinical investigators interested in the biological actions of either natural or synthetic androgens.

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Partial table of contents:

ANDROGEN PHYSIOLOGY.

The Regulation of Leydig Cell Function (D. deKretser, et al.).

Androgen Regulation of Sertoli Cell Function (W. Tribley, et al.).

Androgens and Epididymal Function (M–C.

Orgebin–Crist).

ANDROGEN AND THE PROSTATE.

Androgen Inhibition and BPH (J. Geller).

Androgen Supplementation Causes BPH (J. Pryor).

ANDROGEN: EFFECTS ON THE BRAIN: COGNITIVE, SEXUAL, AND AGGRESSIVE BEHAVIOR.

Androgens and Sexual Differentiation of the Brain (R. Gorski).

Androgens and Cognitive Function (G. Alexander).

EFFECTS ON METABOLISM.

Androgen Effects on Body Composition and Muscle Performance (R. Casaburi, et al.).

Androgen Abuse by Athletes (D. Catlin).

ANDROGEN THERAPY.

Androgen Therapy in Aging Men (J. Tenover).

Androgen Use in Women (B. Sherwin).

ANDROGENS AND MALE CONTRACEPTION.

The Need for Male Nonbarrier Contraception Methods (C. Paulsen).

GnRH Analogues and Male Contraception (R. Swerdloff, et al.).

ANDROGEN DELIVERY SYSTEMS.

Testosterone Transdermal Delivery System (G. Cunningham, et al.).

WORKSHOP PARTICIPANTS.

Index.
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Chuck Kelly
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