The chemistry of reactive intermediates is central to a modern mechanistic and quantitative understanding of organic chemistry. Moreover, it underlies a significant portion of modern synthetic chemistry and is integral to a molecular view of biological chemistry.
Reactive Intermediate Chemistry presents an up–to–date, authoritative guide to this fundamental area of organic chemistry. Intended as a free–standing resource for the entire chemical community, it should be especially useful for graduate students as a primary or supplemental textbook. This volume features a "three–dimensional" approach in which reactive intermediates are considered by class, the kinetic realms they inhabit, and in historical context, connecting the older, product–based chemistry with contemporary direct observational and computational approaches. Other features include:
- Discussion of emerging areas involving dynamics and theory
- A list of suggested reading for each chapter, as well as extensive referencing
- Concluding sections that identify key research directions for the future
Reactive Intermediate Chemistry is a clearly organized, accessible reference for the student or professional in academic, pharmaceutical, or industrial laboratories.
PART 1: REACTIVE INTERMEDIATES.
1. Carbocations (R.A. McClelland).
2. Crossing the Borderline Between SN1 and SN2 Nucleophilic Substitution at Aliphatic Carbon(T.L. Amyes, et al.).
3. Carbanions (S. Gronert).
4. Radicals (M. Newcomb).
5. Non–Kekul Molecules as Reactive Intermediates (J.A. Berson).
6. Organic Radical Ions (H.D. Roth).
7. Singlet Carbenes (M. Jones Jr. and R.A. Moss).
8. Stable Singlet Carbenes (G. Bertrand).
9. Triplet Carbenes (H. Tomioka).
10. Atomic Carbon (P.B. Shevlin).
11. Nitrenes (M.S. Platz).
12. Synthetic Carbene and Nitrene Chemistry (M.P. Doyle).
13. Nitrenium Ions (D.E. Falvey).
14. Silylenes (W. Ando and N. Tokitoh).
15. Strained Hydrocarbons: Structures, Stability, and Reactivity (K.B. Wiberg).
16. Arynes (M. Winkler, et al.).
PART 2: METHODS AND TEMPORAL REGIMES.
17. Matrix Isolation (T. Bally).
18. Nanosecond Laser Flash Photolysis: A Tool for Physica l Organic Chemistry (J.C. Scaiano).
19. The Picosecond Realm (E. Hilinski).
20. Reactions on the Femtosecond Time Scale (J.E. Baldwin).
21. Potential Energy Surfaces and Reaction Dynamics (B.K. Carpenter).
22. The Partnership Between Electronic Structure Calculations and Experiments in the Study of Reactive Intermediates (W.T. Borden).