This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.
This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology:
- Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization
- Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers
- Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods
Part I: Biochemistry and Molecular Biology.
Chapter 1: The Dopamine Transporter: An Anatomical Perspective (Hilary R. Smith, Thomas J. Beveridge, Colleen A. Hanlon, Linda J. Porrino).
Chapter 2: Dopamine Transporter, Disease States and Pathology (Deborah C. Mash).
Chapter 3: Cloning and Genetic Analysis of Dopamine Transporters (David J. Vandenbergh).
Chapter 4: Molecular Structure and Composition of Dopamine Transporters (M. Laura Parnas and Roxanne A. Vaughan).
Chapter 5: Electrochemical Characterization of Dopamine Transporters (Evgeny A. Budygin and Sara R. Jones).
Part II: Medicinal Chemistry.
Chapter 6: Tropane-Based Dopamine Transporter-uptake Inhibitors (Scott P. Runyon and F. Ivy Carroll).
Chapter 7: The Benztropines: Atypical Dopamine-Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter (Amy Hauck Newman and Jonathan L. Katz).
Chapter 8. Structure-Activity Relationship of GBR 12909 Ligands (Thomas E. Prisinzano and Kenner C. Rice).
Chapter 9: Structure-Activity Relationship Study of Piperidine Derivatives for Dopamine Transporters (Prashant S. Kharkar, Maarten E. A. Reith, and Aloke K. Dutta).
Chapter 10: Non-Nitrogen-Containing Dopamine Transporter-Uptake Inhibitors (Peter C. Meltzer).
Chapter 11: Dopamine-Releasing Agents (Bruce E. Blough).
Part III: Pharmacology.
Chapter 12: PET/SPECT Imaging Studies of the Plasma Membrane Dopamine Transporter. (Paul Cumming, Weiguo Ye, Dean F. Wong).
Chapter 13: In Vitro Studies of Dopamine Transporter Function and Regulation (Brian R. Hoover, Bruce H. Mandt and Nancy R. Zahniser).
Chapter 14: In Vivo Studies of Dopamine Transporter Function (Jane B. Acri).