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Algorithms in Computational Molecular Biology. Techniques, Approaches and Applications. Wiley Series in Bioinformatics

  • ID: 2174972
  • Book
  • February 2011
  • Region: Global
  • 1080 Pages
  • John Wiley and Sons Ltd
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The most comprehensive, practical overview of algorithms in computational molecular biology

Computational molecular biology has emerged from the Human Genome Project as an important discipline for academic research and industrial application. Due to the exponential growth?in the size of biological databases and the increasing intricacy of biological problems, high–performance algorithms are now necessary to deal with errors in biological sequences.?Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology is the first in–depth examination of these important algorithms, which are based on the newest and most improved approaches and techniques in the field.

The book′s unique coverage offers both a wide range of information from theintroductory fundamentals right up to the latest, most advanced levels of study and enough technical depth to be of practical use to working professionals. Organized into seven parts, it addresses:

  • Strings processing and application to biological sequences

  • Analysis of biological sequences

  • Motif finding and structure prediction

  • Phylogeny reconstruction

  • Microarray data analysis

  • Analysis of genomes

  • Analysis of biological networks

Also featured are a combination of experiments and simulations that provide not only qualitative but also quantitative insights into this rich field. By covering a wide range of combinatorial problems that arise in computational molecular biology, this book enables researchers, computer scientists, life scientists, mathematicians, graduate students, and senior undergraduates to deal with more complex issues and richer data sets.

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PREFACE xxxi

CONTRIBUTORS xxxiii

I STRINGS PROCESSING AND APPLICATION TO BIOLOGICAL SEQUENCES 1

1 STRING DATA STRUCTURES FOR COMPUTATIONAL MOLECULAR BIOLOGY 3
Christos Makris and Evangelos Theodoridis

2 EFFICIENT RESTRICTED–CASE ALGORITHMS FOR PROBLEMS IN COMPUTATIONAL BIOLOGY 27
Patricia A. Evans and H. Todd Wareham

3 FINITE AUTOMATA IN PATTERN MATCHING 51
Jan Holub

4 NEW DEVELOPMENTS IN PROCESSING OF DEGENERATE SEQUENCES 73
Pavlos Antoniou and Costas S. Iliopoulos

5 EXACT SEARCH ALGORITHMS FOR BIOLOGICAL SEQUENCES 91
Eric Rivals, Leena Salmela, and Jorma Tarhio

6 ALGORITHMIC ASPECTS OF ARC–ANNOTATED SEQUENCES 113
Guillaume Blin, Maxime Crochemore, and Stéphane Vialette

7 ALGORITHMIC ISSUES IN DNA BARCODING PROBLEMS 129
Bhaskar DasGupta, Ming–Yang Kao, and Ion Mandoiu

8 RECENT ADVANCES IN WEIGHTED DNA SEQUENCES 143
Manolis Christodoulakis and Costas S. Iliopoulos

9 DNA COMPUTING FOR SUBGRAPH ISOMORPHISM PROBLEM AND RELATED PROBLEMS 171
Sun–Yuan Hsieh, Chao–Wen Huang, and Hsin–Hung Chou

II ANALYSIS OF BIOLOGICAL SEQUENCES 191

10 GRAPHS IN BIOINFORMATICS 193
Elsa Chacko and Shoba Ranganathan

11 A FLEXIBLE DATA STORE FOR MANAGING BIOINFORMATICS DATA 221
Bassam A. Alqaralleh, Chen Wang, Bing Bing Zhou, and Albert Y. Zomaya

12 ALGORITHMS FOR THE ALIGNMENT OF BIOLOGICAL SEQUENCES 241
Ahmed Mokaddem and Mourad Elloumi

13 ALGORITHMS FOR LOCAL STRUCTURAL ALIGNMENT AND STRUCTURAL MOTIF IDENTIFICATION 261
Sanguthevar Rajasekaran, Vamsi Kundeti, and Martin Schiller

14 EVOLUTION OF THE CLUSTAL FAMILY OF MULTIPLE SEQUENCE ALIGNMENT PROGRAMS 277
Mohamed Radhouene Aniba and Julie Thompson

15 FILTERS AND SEEDS APPROACHES FOR FAST HOMOLOGY SEARCHES IN LARGE DATASETS 299
Nadia Pisanti, Mathieu Giraud, and Pierre Peterlongo

16 NOVEL COMBINATORIAL AND INFORMATION–THEORETIC ALIGNMENT–FREE DISTANCES FOR BIOLOGICAL DATA MINING 321
Chiara Epifanio, Alessandra Gabriele, Raffaele Giancarlo, and Marinella Sciortino

17 IN SILICO METHODS FOR THE ANALYSIS OF METABOLITES AND DRUG MOLECULES 361
Varun Khanna and Shoba Ranganathan

III MOTIF FINDING AND STRUCTURE PREDICTION 383

18 MOTIF FINDING ALGORITHMS IN BIOLOGICAL SEQUENCES 385
Tarek El Falah, Mourad Elloumi, and Thierry Lecroq

19 COMPUTATIONAL CHARACTERIZATION OF REGULATORY REGIONS 397
Enrique Blanco

20 ALGORITHMIC ISSUES IN THE ANALYSIS OF CHIP–SEQ DATA 425
Federico Zambelli and Giulio Pavesi

21 APPROACHES AND METHODS FOR OPERON PREDICTION BASED ON MACHINE LEARNING TECHNIQUES 449
Yan Wang, You Zhou, Chunguang Zhou, Shuqin Wang, Wei Du, Chen Zhang, and Yanchun Liang

22 PROTEIN FUNCTION PREDICTION WITH DATA–MINING TECHNIQUES 479
Xing–Ming Zhao and Luonan Chen

23 PROTEIN DOMAIN BOUNDARY PREDICTION 501
Paul D. Yoo, Bing Bing Zhou, and Albert Y. Zomaya

24 AN INTRODUCTION TO RNA STRUCTURE AND PSEUDOKNOT PREDICTION 521
Jana Sperschneider and Amitava Datta

IV PHYLOGENY RECONSTRUCTION 547

25 PHYLOGENETIC SEARCH ALGORITHMS FOR MAXIMUM LIKELIHOOD 549
Alexandros Stamatakis

26 HEURISTIC METHODS FOR PHYLOGENETIC RECONSTRUCTION WITH MAXIMUM PARSIMONY 579
Adrien Goëffon, Jean–Michel Richer, and Jin–Kao Hao

27 MAXIMUM ENTROPY METHOD FOR COMPOSITION VECTOR METHOD 599
Raymond H.–F. Chan, Roger W. Wang, and Jeff C.–F. Wong

V MICROARRAY DATA ANALYSIS 623

28 MICROARRAY GENE EXPRESSION DATA ANALYSIS 625
Alan Wee–Chung Liew and Xiangchao Gan

29 BICLUSTERING OF MICROARRAY DATA 651
Wassim Ayadi and Mourad Elloumi

30 COMPUTATIONAL MODELS FOR CONDITION–SPECIFIC GENE AND PATHWAY INFERENCE 665
Yu–Qing Qiu, Shihua Zhang, Xiang–Sun Zhang, and Luonan Chen

31 HETEROGENEITY OF DIFFERENTIAL EXPRESSION IN CANCER STUDIES: ALGORITHMS AND METHODS 691
Radha Krishna Murthy Karuturi

VI ANALYSIS OF GENOMES 723

32 COMPARATIVE GENOMICS: ALGORITHMS AND APPLICATIONS 725
Xiao Yang and Srinivas Aluru

33 ADVANCES IN GENOME REARRANGEMENT ALGORITHMS 749
Masud Hasan and M. Sohel Rahman

34 COMPUTING GENOMIC DISTANCES: AN ALGORITHMIC VIEWPOINT 773
Guillaume Fertin and Irena Rusu

35 WAVELET ALGORITHMS FOR DNA ANALYSIS 799
Carlo Cattani

36 HAPLOTYPE INFERENCE MODELS AND ALGORITHMS 843
Ling–Yun Wu

VII ANALYSIS OF BIOLOGICAL NETWORKS 865

37 UNTANGLING BIOLOGICAL NETWORKS USING BIOINFORMATICS 867
Gaurav Kumar, Adrian P. Cootes, and Shoba Ranganathan

38 PROBABILISTIC APPROACHES FOR INVESTIGATING BIOLOGICAL NETWORKS 893
Jérémie Bourdon and Damien Eveillard

39 MODELING AND ANALYSIS OF BIOLOGICAL NETWORKS WITH MODEL CHECKING 915
Dragan Bosnacki, Peter A.J. Hilbers, Ronny S. Mans, and Erik P. de Vink

40 REVERSE ENGINEERING OF MOLECULAR NETWORKS FROM A COMMON COMBINATORIAL APPROACH 941
Bhaskar DasGupta, Paola Vera–Licona, and Eduardo Sontag

41 UNSUPERVISED LEARNING FOR GENE REGULATION NETWORK INFERENCE FROM EXPRESSION DATA: A REVIEW 955
Mohamed Elati and Céline Rouveirol

42 APPROACHES TO CONSTRUCTION AND ANALYSIS OF MICRORNA–MEDIATED NETWORKS 979
Ilana Lichtenstein, Albert Zomaya, Jennifer Gamble, and Mathew Vadas

INDEX 1007

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Mourad Elloumi
Albert Y. Zomaya
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