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Therapeutic Targets. Modulation, Inhibition, and Activation. Edition No. 1

  • ID: 2175025
  • Book
  • June 2012
  • 502 Pages
  • John Wiley and Sons Ltd

The Latest Applications For Cellmechanism Research in Drug Discovery

Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe.

The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more.

Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.

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Preface vii

Contributors ix

1. cAMP-Specific Phosphodiesterases: Modulation, Inhibition, and Activation 1
R. T. Cameron and George S. Baillie

2. Protease-Activated Receptor 2 37
Qihai Gu and Lu-Yuan Lee

3. Voltage-Gated Sodium Channels as Therapeutic Targets 63
Joshua S. Wingerd, Irina Vetter, and Richard J. Lewis

4. Multitarget Drugs for Stabilization of Calcium Cycling and Neuroprotection in Neurodegenerative Diseases and Stroke 123
Antonio M. G. de Diego, Silvia Lorrio, Jesús M. Hernández-Guijo, Luis Gandía, and Antonio G. García

5. Oligomerization of G-Protein-Coupled Receptors 201
Juan F. López-Giménez and Javier González-Maeso

6. Sigma 1 Receptor Chaperone: Pharmacology and Therapeutic Perspectives 225
Daniel Zamanillo, Enrique Portillo-Salido, José Miguel Vela, and Luz Romero

7. Lipids as New Targets 279
Eduardo Domúnguez

8. Knowledge Base for Nuclear Receptor Drug Discovery 309
Albert A. Antolín and Jordi Mestres

9. Gene Promoters and Transcription Control Regions as Therapeutic Targets 327
Antonio Zorzano, David Sebastian, Jana Sánchez-Wandelmer, Laia Miret, and Fernando Albericio

10. Roles of Glucagon-Like Peptide and Glucose-Dependent Insolinotropic Polypeptide Hormones in Brain Function and Neurodegeneration 351
Christian Hölscher

11. Exocytotic Machinery as a Target for the Development of New Drugs for Schizophrenia 375
María Jose Guerrero, Itsaso Hormaeche, María Uribarri, Julie Masse, and José María Palacios

12. Targeting Epigenetic Abnormalities in the Brain 409
Erin Y. Sterner, Lisa E. Kalynchuk, and Hector J. Caruncho

13. Rodent Models as Tools for Discovering Novel Therapeutic Targets in the Brain: The Case of Epilepsy 427
Justin J. Botterill, Axel J. Guskjolen, Lisa E. Kalynchuk, and Hector J. Caruncho

14. New Approaches Applied to Drug Screening 455
José Brea and María Isabel Loza

Index 477

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Mabel Loza
Luis M. Botana University of Santiago de Compostela.
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