The Latest Applications For Cellmechanism Research in Drug Discovery
Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe.
The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein–coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more.
Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer′s, diabetes, pain, and inflammation treatments. Concluding with a cross–sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
1. cAMP–Specific Phosphodiesterases: Modulation, Inhibition, and Activation 1R. T. Cameron and George S. Baillie
2. Protease–Activated Receptor 2 37Qihai Gu and Lu–Yuan Lee
3. Voltage–Gated Sodium Channels as Therapeutic Targets 63Joshua S. Wingerd, Irina Vetter, and Richard J. Lewis
4. Multitarget Drugs for Stabilization of Calcium Cycling and Neuroprotection in Neurodegenerative Diseases and Stroke 123Antonio M. G. de Diego, Silvia Lorrio, Jesús M. Hernández–Guijo, Luis Gandía, and Antonio G. García
5. Oligomerization of G–Protein–Coupled Receptors 201Juan F. López–Giménez and Javier González–Maeso
6. Sigma 1 Receptor Chaperone: Pharmacology and Therapeutic Perspectives 225Daniel Zamanillo, Enrique Portillo–Salido, José Miguel Vela, and Luz Romero
7. Lipids as New Targets 279Eduardo Domúnguez
8. Knowledge Base for Nuclear Receptor Drug Discovery 309Albert A. Antolín and Jordi Mestres
9. Gene Promoters and Transcription Control Regions as Therapeutic Targets 327Antonio Zorzano, David Sebastian, Jana Sánchez–Wandelmer, Laia Miret, and Fernando Albericio
10. Roles of Glucagon–Like Peptide and Glucose–Dependent Insolinotropic Polypeptide Hormones in Brain Function and Neurodegeneration 351Christian Hölscher
11. Exocytotic Machinery as a Target for the Development of New Drugs for Schizophrenia 375María Jose Guerrero, Itsaso Hormaeche, María Uribarri, Julie Masse, and José María Palacios
12. Targeting Epigenetic Abnormalities in the Brain 409Erin Y. Sterner, Lisa E. Kalynchuk, and Hector J. Caruncho
13. Rodent Models as Tools for Discovering Novel Therapeutic Targets in the Brain: The Case of Epilepsy 427Justin J. Botterill, Axel J. Guskjolen, Lisa E. Kalynchuk, and Hector J. Caruncho
14. New Approaches Applied to Drug Screening 455José Brea and María Isabel Loza
In summary, there are a number of well–written and constructed, comprehensive monographs that will be of interest to experts. (ChemMedChem, 1 March 2013)
The degree to which an integrated, unified, and visionary perspective emerges across the book is limited. Nonetheless, individual chapters are likely to be very useful to readers in that specific research area. The book certainly offers descriptions of several active target development approaches and application of such approaches in specific biological systems. (Doody s, 1 March 2013)