Cutting–edge technological developments at the intersection of electronics and biology
The application of electronics to biology and medicine has resulted in important healthcare technologies ranging from the cardiac pacemaker to the blood glucose meter. The next generation of healthcare technology will be enabled by bioelectronics, a frontier discipline emerging at the interfaces of electronics, biology, physics, chemistry, and materials science. This unique book reveals the state of the art in this exciting field, presenting a wide range of applications and examples of advanced CMOS (complementary metal oxide semiconductor) microsystems that interface with biology.
Written by top international experts in industry and academia, this is the first volume to cover bio–microsystems that integrate microelectronics with fluidics, photonics, and mechanics. Divided into three major parts that focus on human body monitoring, biosensors and circuits, and emerging technologies, this book offers a wealth of information on emerging topics in bioelectronics most of which has only been previously available in specialized journals and at research conferences. Coverage includes:
The potential behind new interfaces (with biology, microfluidics, microelectromechanical systems, photonics) that will carry circuit performance beyond standard CMOS chip microelectronics
Fully integrated systems for neural signal recording
Design considerations of low–power digital–integrated systems for the implantable medical application
CMOS capacitive biointerfaces for lab–on–chip applications
Advanced technologies for real–time monitoring and control in biomicrofluidics
Integrated devices and many other emerging device structures needed in future micro/nanotechnologies
Groundbreaking research in humans controlling biological organisms
Complete with extensive cross–references, CMOS Biomicrosystems is a valuable resource for electrical, mechanical, materials science, and micro/nano engineers as well as researchers who focus on the integration of microelectronics. It is also useful as supplementary material in graduate courses in electrical engineering, microelectronics, CMOS circuit design, and biomedical devices.
PART I: HUMAN BODY MONITORING.
1 INTERFACING BIOLOGY AND CIRCUITS: QUANTIFICATION AND PERFORMANCE METRICS (Alexander J. Casson and Esther Rodriguez–Villegas).
2 FULLY INTEGRATED SYSTEMS FOR NEURAL SIGNAL RECORDING: TECHNOLOGY PERSPECTIVE AND LOW–NOISE FRONT–END DESIGN (Andrea Bonfanti, Tommaso Borghi, Guido Zambra, and Andrea L. Lacaita).
3 VLSI IMPLEMENTATION OF WIRELESS NEURAL RECORDING MICROSYSTEM FOR NEUROMUSCULAR STIMULATION (Shuenn–Yuh Lee, Chih–Jen Cheng, Shyh–Chyang Lee, and Qiang Fang).
4 HEALTH–CARE DEVICES USING RADIO FREQUENCY TECHNOLOGY (Jung Han Choi and Dong Kyun Kim).
5 DESIGN CONSIDERATIONS OF LOW–POWER DIGITAL INTEGRATED SYSTEMS FOR IMPLANTABLE MEDICAL APPLICATIONS (Zhihua Wang, Xiang Xie, Xinkai Chen, and Xiaowen Li).
PART II: BIOSENSORS AND CIRCUITS.
6 AFFINITY–BASED BIOSENSORS: STOCHASTIC MODELING AND FIGURES OF MERIT (Shreepriya Das, Haris Vikalo, and Arjang Hassibi).
7 FABRICATION EXAMPLES BASED ON STANDARD CMOS AND MEMS PROCESSES (Bernard Courtois).
8 CMOS CAPACITIVE BIOINTERFACES FOR LAB–ON–CHIP APPLICATIONS (Ebrahim Ghafar–Zadeh).
9 LENSFREE IMAGING CYTOMETRY AND DIAGNOSTICS FOR POINT–OF–CARE AND TELEMEDICINE APPLICATIONS (Sungkyu Seo, Ting–Wei Su, Anthony Erlinger, and Aydogan Ozcan).
10 ADVANCED TECHNOLOGIES FOR REAL–TIME MONITORING AND CONTROL IN BIOMICROFLUIDICS (Francesca Sapuppo, Marcos Intaglietta, and Maide Bucolo).
11 MONITORING OF STEM CELL CULTURE PROCESS USING ELECTROCHEMICAL BIOSENSORS (Xicai Yue and Emmanuel M. Drakakis).
PART III: EMERGING TECHNOLOGIES.
12 BUILDING INTERFACES TO DEVELOPING CELLS AND ORGANISMS: FROM CYBORG BEETLES TO SYNTHETIC BIOLOGY (Hirotaka Sato, Daniel Cohen, and Michel M. Maharbiz).
13 TECHNOLOGIES FOR ARRAYED SINGLE–CELL BIOLOGY (Sarah C. McQuaide, James R. Etzkorn, and Babak A. Parviz).
14 APPLICATION OF BACTERIAL FLAGELLAR MOTORS IN MICROFLUIDIC SYSTEMS (Steve Tung, Jin–Woo Kim, and Ryan Pooran).
15 GENE INJECTION AND MANIPULATION USING CMOS–BASED TECHNOLOGIES (Arati Sridharan and Jit Muthuswamy).
16 LOW–COST DIAGNOSTICS: RF DESIGNER S APPROACH (Nan Sun, Yong Liu, and Donhee Ham).
KRZYSZTOF INIEWSKI, PhD, is a well–known international expert in emerging technologies in wireless communications, medical imaging, semiconductor devices, and nanoelectronics. Currently, he manages R&D developments at Redlen Technologies, a start–up company in British Columbia. He is also an Executive Director of CMOS Emerging Technologies, Inc. Dr. Iniewski has published more than one hundred research papers in international journals and conferences, and he is a frequent invited speaker who presents at various international events. He holds eighteen international patents granted in the United States, Canada, France, Germany, and Japan.