Dr. Oljan Repic clearly explains the goals and basic principles of chemical development. He explores the crucial aspects of a new process that must be considered when scaling up a research synthesis to industrial levels. And, with the help of many fascinating case studies and vignettes, he delineates each phase of the development process. Key topics include:
∗ Qualities of an ideal process
∗ Techniques for minimizing impurities
∗ Criteria for cost–effective synthesis of enantiopure compounds by resolutions
∗ Asymmetric synthesis and the "chiral pool" strategy
∗ Synthesis for labeling substances with hydrogen or carbon isotopes
∗ New drug registration requirements
Writing with candor, wit, and an unflagging enthusiasm for his chosen profession, Dr. Repic vividly chronicles the challenges, disappointments, and rewards experienced by the member of a chemical development team responsible for bringing a lifesaving drug to market. This book is an invaluable reference for professionals as well as an important source of guidance and inspiration for young chemists considering entering the field.