Principles and Applications of Asymmetric Synthesis

  • ID: 2175553
  • Book
  • 536 Pages
  • John Wiley and Sons Ltd
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Convenient reference covering one of the most important topics in chemical research today

Principles and Applications of Asymmetric Synthesis

Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one–volume resource for the convenience of practicing scientists and students.

Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as well as catalytic asymmetric reactions. The first chapter reviews the basic principles, common nomenclature, and analytical methods, and the remainder of the book is organized according to reaction type. The text examines such topics as:

∗ Carbon–carbon bond formations involving carbonyls, enamines, imines, and enolates

∗ Asymmetric C–O bond formations including epoxidation, dihydroxylation, and aminohydroxylation

∗ Asymmetric synthesis using the Diels–Alder reaction and other cyclizations

∗ Applications to the total synthesis of natural products

∗ Use of enzymes in asymmetric synthesis

Practicing chemists in the pharmaceutical, fine chemical, and agricultural professions as well as graduate students will find that Principles and Applications of Asymmetric Synthesis affords comprehensive and current coverage.
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–Alkylation and Catalytic Alkylation of Carbonyl Compounds.

Aldol and Related Reactions.

Asymmetric Oxidations.

Asymmetric Diels–Alder and Other Cyclization Reactions.

Asymmetric Catalytic Hydrogenation and Other Reduction Reactions.

Applications of Asymmetric Reactions in the Synthesis of Natural Products.

Enzymatic Reactions and Miscellaneous Asymmetic Syntheses.

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"Lin and colleagues...consolidate and evaluate the most useful methodologies for producing enantiomerically pure or enriched compounds." (SciTech Book News, Vol. 25, No. 3, September 2001)

"...a concise and fairly comprehensive overview..." (Angewandte Chemie, 15 October 2001)

"...this book is worthy of purchase for library collections and for chemists who would like to have a one–volume summary of the last 20 years of asymmetric synthesis. Those actively involved in asymmetric synthesis research will find this book most useful..." (Journal of Natural Products, Vol. 64, 2001)

"...a very good review of basic asymmetric methodology that can be recommended to students of organic chemistry..." (Journal of Medicinal Chemistry, Vol. 44, No. 26 2001)

"a well balanced survey of stereocontrolled methodologies and synthetic applications from which the reader can achieve valuable information." (ChemWeb, 14 January 2002)

"This book is quite readable and is highly recommended for those clinicians and administrators who want or need a practical and time–effective way to approach assessment, treatment planning and outcome measurement." (Keith Harris, Ph.D., clinical psychologist and supervisor of Victor Valley Behavioral Health Center, San Bernardino, California).

"There are many books on asymmetric synthesis, but this one of the most useful and comprehensive" (Organic Process Research & Development)
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