Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text:
- Presents real experimental data
- Describes organ site–specific mouse models
- Clearly identifies suitable models for further drug testing
- Critically analyzes current methodologies and their limitations
- Features numerous recognizable expert contributors
- Lists key Web sites, reagents, and companies
From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ–specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions.
Combining stellar chapter authors, rich illustrations, and clear, up–to–date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting–edge researchers.
PART I: MOUSE HANDLING AND ENGINEERING.
1. Approaches to Handling, Breeding, Strain Preservation, Genotyping, and Drug Administration for Mouse Models of Cancer (Dawnalyn Boggess, Kathleen A. Silva, Carlisle P. Landel, Larry Mobraaten, and John P. Sundberg).
2. Pathology of Mouse Models of Cancer (Robert D. Cardiff).
3. Intercurrent Infections in Genetically Engineered Mice (Stephen W. Barthold).
4. Germline Modification Strategies (Silvia Grisendi and Pier Paolo Pandolfi).
5. Somatic Cell Gene Transfer (Lene Uhrbom and Eric C. Holland).
PART II: ORGAN SITE SPECIFIC MOUSE MODELS OF HUMAN CANCER.
6. Lung Cancer (Jonathan M. Kurie, Parviz Minoo, Stephen S. Hecht, Alexander Nikitin, and Franco J. DeMayo).
7. Mammary Gland Cancer (Dalit Barkan, Cristina Montagna, Thomas Ried, and Jeffrey E. Green).
8. Prostate Cancer (Katharine Ellwood–Yen and Charles Sawyers).
9. Skin Cancer (Marcus Bosenberg).
10. Ovarian Cancer (Sandra Orsulic).
11. Peripheral Nervous System Tumors (David H. Gutmann, Arie Perry, Reshma Rangwala, and Larry S. Sherman).
12. Central Nervous System Tumors (Andrew B. Lassman and Eric C. Holland).
13. Myeloid Malignancies (Scott C. Kogan).
14. Lymphoid Malignancies (Michael Teitell and Pier Paolo Pandolfi).
PART III: GENERAL ISSUES IN CANCER BIOLOGY.
15. Genetic Modifiers (David W. Threadgill, Kent W. Hunter, Fei Zou, and Kenneth F. Manly).
16. Modeling Blood Vessel Formation in the Mouse (Robert Benezra, Shahin Rafii, and David Lyden).
17. Metastasis (Dawn S. Chandler and Guillermina Lozano).
18. Immunologic Study of Tumors in Mouse Models (Taha Merghoub and Alan N. Houghton).
PART IV: IMAGING TECHNOLOGIES.
19. Micro Computed Tomography of Mouse Cancer Models (Jamey P. Weichert).
20 .Magnetic Resonance Imaging in Mouse Cancer Models (Manickam Muruganandham and Jason A. Koutcher).
21. Bioluminescent Imaging of Mouse Cancer Models (Christopher H. Contag).
PART V: PRECLINICAL TRIALS.
22 .Use of Magnetic Resonance Imaging for Evaluation of Treatment Response (Brian D. Ross, Thomas L. Chenevert, Bradford A. Moffat, Alnawaz Rehemtulla, Daniel E. Hall, Patrick McConville, and Jonathan Moody).
23. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling (Raymond S. H. Yang, James E. Dennison, Melvin E. Andersen, Ying C. Ou, Kai H. Liao, and Brad Reisfeld).
24. Trial Design and Biostatistics (Michael F. W. Festing).
25. Cancer Drug Development in the Modern Era (William R. Sellers and Alex Matter).
26. Preclinical Trials in Mouse Cancer Models (Brian Weiss and Kevin Shannon).