Presenting the latest research in cancer biology, Cancer Epigenetics reveals the most promising developments in novel therapeutics and diagnostic options for cancer patients. Featuring contributions from international authorities in diverse disciplines, the book offers clear therapeutic approaches and applications and facilitates collaboration between the basic, translational, and clinical sciences.
This volume is divided into five sections:
Epigenetics and cell cycle
Epigenetics and cell development, senescence and differentiation
Epigenetics and gene transcription
Epigenetics and cancer
Epigenetics and anticancer drug development and therapy
Emphasizing practical applications of research, Cancer Epigenetics provides comprehensive coverage of therapeutic approaches in clinical testing and at the final stages of pre–clinical development. It also discusses new advances in the development of novel therapeutics, including angiogenesis inhibitors and antiretroviral therapies.
Research and clinical oncologists, translational cancer researchers, health professionals dealing with cancer science and therapies, and medical and biomedical science students will rely on this timely and authoritative resource.
Cover Art: The cover image shows an original piece of artwork by a renowned Italian artist Lello Esposito. It depicts nucleotides and a tumor cell, which of course relates directly to the theme of this new book. Mr. Esposito dedicated this piece to the Sbarro Health Research Organization.
SECTION I: EPIGENETICS AND CELL CYCLE.
1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela Montanari, Antonio Giordano, Marcella Cintorino, and Marcella Macaluso).
SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND DIFFERENTIATION.
2 Epigenetics in Skeletal Muscle Development (Cristina Giacinti and Antonio Giordano).
3 Epigenetic Control in Cellular Senescence (Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn).
4 Epigenetic Modulation in Cell Development and Differentiation (Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca, and Francesca Pentimalli).
SECTION III: EPIGENETICS AND GENE TRANSCRIPTION.
5 Epigenetic Control of Gene Transcription (Christian Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B. Schini–Kerth).
6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia Cito, Debora Muresu, Flavio Rizzolio, and Antonio Giordano).
SECTION IV: EPIGENETICS AND CANCER.
7 The Role of Epigenetic Modifications in Cancer (Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander Mazo, and Richard G. Pestell).
8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso Bellacosa).
9 Epigenetics in Pediatric Cancers (Roberta Ciarapica, Lavinia Raimondi, Federica Verginelli, and Rossella Rota).
10 Epigenetic Mechanisms in Cancer Formation and Progression (Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral, and Michele Maio).
SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND THERAPY.
11 Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency (Gaetano Romano).
12 Potential of Heat Shock Protein Targeting for Human Therapy (Laszlo Otvos, Jr).
13 Advances in Stem Cell Therapy for Cancer Research (Andrew Puca and Antonio Giordano).
14 Epigenetic Targets and Drug Development (Paraskevi Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio).
In summary, this book provides a useful in–depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast–moving field and will be most accessible to those with a biological background and interest. (ChemMedChem, 1 July 2013)