Published almost a decade ago, the first edition has served as the guide for research in this burgeoning field. Due to the cost, safety, efficiency, and environmental friendliness of water as a solvent, there are many new applications in industry and academic laboratories. More than forty percent of this extensively updated second edition covers new reactions. For ease of reference, it is organized by functional groups. A core reference, Comprehensive Organic Reactions in Aqueous Media, Second Edition:
Provides the most comprehensive coverage of aqueous organicreactions available
Covers the basic principles and theory and progresses to applications
Includes alkanes, alkenes, aromatics, electrophilic substitutions, carbonyls, alpha, beta–unsaturated carbonyls, carbon–nitrogen bonds, organic halides, pericyclic reactions, photochemical reactions, click chemistry, and multi–step syntheses?
Provides examples of applications in industry
This is the premier reference for chemists and chemical engineers in industry or research, as well as for students in advanced–level courses.
1.1 The Structure and Forms of Water.
1.2 Properties of Water.
1.4 Hydrophobic Effect.
1.5 Salt Effect.
1.6 Water Under Extreme Conditions.
2.1 Oxygenation of Alkanes.
2.2 Halogenation of Alkanes.
2.3 Formation of Carbon Carbon Bonds.
2.4 D/H Exchange of Alkanes in Water.
3.2 Electrophilic Additions.
3.3 Radical Reactions of Alkenes.
3.4 Carbene Reactions.
3.5 Alkene Isomerization.
3.6 Transition–Metal Catalyzed C C Formation Reactions.
3.7 Olefin Metathesis.
3.8 Reaction of Allylic C H Bond.
4.1 Reaction of Terminal Alkynes.
4.2 Additions of C C bonds.
4.3 Transition–Metal Catalyzed Cycloadditions.
4.4 Other Reactions.
5. ALCOHOLS, PHENOLS, ETHERS, THIOLS, AND THIOETHERS.
5.1 Oxidation of Alcohols.
5.3 Addition of Alcohols, Phenols, and Thiols to Alkene and Alkyne Bonds.
5.4 Addition of Alcohols to C=O Bonds: Esterification and Acetal Formations.
5.5 Reaction of Ethers and Cyclic Ethers.
5.6 Reaction of Sulfur Compounds.
6. ORGANIC HALIDES.
6.3 Elimination Reactions.
6.4 Nucleophilic Substitutions.
6.5 Reductive Coupling.
6.6 Carbonylation of Organic Halides.
6.7 Transition–Metal Catalyzed Coupling Reactions.
7. AROMATIC COMPOUNDS.
7.2 Substitution Reactions.
7.3 Oxidation Reactions.
8. ALDEHDYE AND KETONES.
8.3 Nucleophilic Addition: C C Bond Formation.
8.4 Pinacol Coupling.
8.5 Other Reactions (Halogenation and Oxidation of –H).
9. CARBOXYLIC ACIDS AND DERIVATIVES.
9.2 Carboxylic Acids.
9.3 Carboxylic Acid Derivatives.
10. CONJUGATED CARBONYL COMPOUNDS.
10.2 Epoxidation, Dihydroxylation, Hydroxyamination.
10.3 Conjugate Addition: Heteroatom.
10.4 C C Bond Formation.
10.5 Other Reactions.
11. NITROGEN COMPOUNDS.
11.3 Diazo Compounds.
11.5 Nitro Compounds.
12. PERICYCLIC REACTIONS.
12.2 Diels–Alder Reactions.
12.3 Sigmatropic Rearrangements.
12.4 Photochemical Cycloaddition Reactions.
" a testament to the enormous expansion in the field of water–based chemistry, and compiling it in a single volume is very useful." (Journal of the American Chemical Society, December 26, 2007)
"Advanced students and research and development chemists with an interest in green chemistry are highly recommended to purchase this book." (Organic Chemistry Portal, January 2008)