∗ A concise introduction to the field of Preimplantation Genetic Diagnosis (PGD)
∗ Detailed explanations of the techniques and procedures used
∗ The law and ethical implications of PGD
∗ Future uses of PGD
Preimplantation Genetic Diagnosis has been carefully written for both the prenatal diagnosis community (clinical geneticists and fetal medicine specialists within obstetrics and gynaecology) and the IVF and reproductive medicine community, with special introductory chapters for non–specialists.
Introduction (J. Harper).
Genetic Basis of Inherited Disease (J. Delhanty).
Prenatal Diagnosis (A. Cockell & C. Rodeck).
Genetic Counselling (S. Raeburn).
In Vitro Fertilization (K. Elder).
Gametogenesis and Preimplantation Embryo Development (K. Elder & S. Fleming).
Preimplantation Genetics (E. Pergament, et al.).
PROCEDURES USED IN PGD.
Clinical Aspects of Preimplantation Diagnosis (C. Overton, et al.).
Embryo Biopsy (J. Harper & A. Thornhill).
Diagnosis of Single Gene Disorders (D. Wells & J. Sherlock).
FISH and Embryo Sexing to Avoid X–linked Disease (J. Harper & L. Wilton).
Preimplantation Genetic Diagnosis of Chromosome Abnormalities: Specific Chromosomal Rearrangements and Age–related Aneuploidy (J. Delhanty & C. Conn).
Ethical Perspectives and Regulation of Preimplantation Genetic Diagnostic Practice (S. Viville, et al.).
Future Developments in PGD (J. Harper & D. Wells).
"This is a welcome and comprehensive introduction to PGD, which I recommend to anyone interested in this exciting and rapidly evolving field." (Human Genetics, Vol.110, 2002)