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Mycobacteria. Molecular Biology and Virulence

  • ID: 2176413
  • Book
  • September 1999
  • 416 Pages
  • John Wiley and Sons Ltd
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Tuberculosis still kills more people than any other single infective agent. The resurgence of the disease in many countries has produce a heightened awareness of the threat posed by mycobacterial infections. At the same time, there has been an explosion of knowledge of the fundamental properties of mycobacteria, most notably the determination of the complete genome sequence of Mycobacterium tuberculosis.

This book provides an up–to–date account of these developments in the molecular biology and immunology of mycobacteria, coupled with allied advances of a more applied nature such as the use of molecular techniques for diagnosis and epidemiological investigations. With chapters contributed from an international team of experts, it will not only be an essential reference text for the expanding mycobacterial research community, but will also find a prominent place on the shelves of clinicians, infectious disease and public health specialists, diagnostic laboratories, postgraduate students and indeed anyone concerned with the management and investigation of outbreaks of tuberculosis.

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List of Contributors.


1 Recombination.

2 Mobile Genetic Elements/Plasmids.

3 Mycobacteriophages.

4 Gene Expression And Regulation.

5 Genomics of Mycobacterium Tuberculosis and Mycobacterium Leprae.

6 Molecular Epidemiology: Human.

7 Molecular Epidemiology: Mycobacterium.

8 Molecular Epidemiology: Other Mycobacteria.

9 Molecular Diagnostics.

10 Immunodiagnosis of Mycobacterial Infection.

11 Mycobacterial Growth and Dormancy.

12 Cell Wall: Physical Structure and Permeability.

13 The Cell–Wall Core of Mycobacterium: Structure, Biogenesis and Genetics.

14 Iron Metabolism.

15 Antibiotic and Antibiotic Resistance in Mycobacteria.

16. Immunotherapy for Mycobacterial Disease.

17 Vaccines.

18 Mycobacterial Antigens.

19 Mycobacterium and the Seduction of the Macrophage.

20 Cytokines in Immunity to Tuberculosis.


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C. Ratledge
J. W. Dale
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