Natural Products in Chemical Biology

  • ID: 2176733
  • Book
  • 436 Pages
  • John Wiley and Sons Ltd
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A timely and authoritative look at the chemistry of natural products

Based on the acclaimed Wiley Encyclopedia of Chemical Biology, this book focuses on natural products and explores their impact on drug discovery and design. With emphasis on the gamut of biological diversity and activities of natural products, the book examines the unique features of these molecules, highlights influences from genetics and biochemistry, and points to promising future trends. Divided into three parts, Natural Products in Chemical Biology first introduces sources of natural products, then goes on to present the biosynthesis of main classes of natural products and their uses in medicine. The book presents fourteen self–contained, peer–reviewed articles carefully selected from the Wiley Encyclopedia of Chemical Biology and new material. Clear, authoritative coverage includes:

  • A discussion of the chemical diversity of plant, marine, and microbial natural products
  • Biosynthesis of nonribosomal peptides, plant terpenoids, polyketides, alkaloids, cofactors, and antibiotics
  • Use of natural products and natural product models in the pharmaceutical industry

Natural Products in Chemical Biology is an excellent introduction to the ongoing research in the chemistry of natural products for researchers in diverse fields, from organic and medicinal chemistry to molecular biology and the pharmaceutical industry.

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Preface vii

Contributors ix

PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS 1

1 Plant Natural Products 3A. Leslie Gunatilaka

2 Marine Natural Products 31Nobuhiro Fusetani

3 Microbial Natural Products 65Sergio Sanchez, Silvia Guzma´n–Trampe, Mariana A´valos, Beatriz Ruiz, Romina Rodr´ýguez–Sanoja, and Manuel Jim´enez–Estrada

PART II BIOSYNTHESIS OF NATURAL PRODUCTS 109

4 Nonribosomal Peptides 111Georg Schoenafinger and Mohamed A. Marahiel

5 Plant Terpenoids 127Christopher I. Keeling and J¨org Bohlmann

6 Polyketides in Fungi 143Thomas J. Simpson and Russell J. Cox

7 Modular Polyketide Synthases 163Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H. Sherman

8 Polyketide Polyethers 189Alison M. Hill

9 Alkaloids 209Sarah E. O Connor

10 Cofactors 239Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich, and Felix Rohdich

11 Antibiotics 269Sergey B. Zotchev

PART III NATURAL PRODUCTS IN MEDICINE 287

12 Pharmaceuticals: Natural Products and Natural Product Models 289Sheo B. Singh

13 Natural Products as Anticancer Agents 325David G. I. Kingston and David J. Newman

14 Plant–Derived Natural Products Research in Drug Discovery 351Kuo–Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L. Morris–Natschke

Index 389

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In summary, this is a really good book from a number of prominent research groups who have made important contributions to their fields.  Some chapters are well suited for newcomers to the subject, as well as for teaching or for reading by interested students.   (Angewandte Chemie International Edition, 19 March 2014)

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