Metal Complex – DNA Interactions

  • ID: 2177086
  • Book
  • 544 Pages
  • John Wiley and Sons Ltd
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The importance of metal–DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today.

This book provides an overview of metal–DNA interactions, the mechanism of their interaction, metal–based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal–based drugs.

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A Basic Structural and Kinetic Aspects

1. Sequence–Selective Binding of Transition Metal Complexes to DNA

2. Thermodynamic Models of Metal Ion –DNA.Interactions

3. Metal Ion Coordination in G–quadruplexes

4. Supramolecular Chemistry of Metal–Nucleobase Complexes

B Medical Applications

5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,

nucleotides and DNA

6. Role of DNA Repair in Antitumor Effects of Platinum Drugs

7. Telomeres and Telomerase: Potential Targets for Platinum Complexes

8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes

9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene


10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA

C DNA–Recognition – Nucleases and Sensors

11. Groove–Binding Ruthenium(II) Complexes as Probes of DNA Recognition

12. DNA Recognition and Binding by Peptide–Metal Complex conjugate

13. Artificial Restriction Agents – Hydrolytic Agents for DNA Cleavage

14. New Metallo–DNAzymes: Fundamental Studies of Metal–DNA Interactions and

Metal Sensing Applications

15. Two–metal Ion Dependent Catalysis in Nucleic Acid Enzymes

D Toxicological aspects

16. Mercury– DNA Interactions. Structural Studies on MercuryII –Mediated T–T Base–Pair with NMR Spectroscopy

17. Chromium–Induced DNA Damage and Repair

18. Arsenic and nickel: Mechanisms Affecting DNA Integrity

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Nick Hadjiliadis
Einar Sletten
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