Solid–Phase Organic Synthesis

  • ID: 2178275
  • Book
  • 296 Pages
  • John Wiley and Sons Ltd
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Solid–Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high–throughput chemistry is now the focus of many research laboratories. Solid–phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution–phase methods to a solid support, while others report major innovations. Solid–Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include:

∗ Syntheses of guanidines

∗ Palladium–catalyzed C–C bond forming reactions

∗ S—nAr reactions for the formation of heterocycles

∗ Sequence–specific arylalkyne oligomers

∗ Resin–supported capture agents and other reagents

∗ Synthesis on pins

∗ Monitoring of supported reactions using IR

∗ Solid–phase syntheses of natural product derivatives

Of related interest ... Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0–471–15518–7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0–471–12687–X) 288 pp.
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Solid Phase Syntheses of Guanidines (K. Burgess & J. Chen).

Palladium–catalyzed Carbon–carbon Bond Formation on Solid Supports (M. Todd & C. Abell).

Benzofused Heterocycles via Solid–phase S—NAr Reactions (M. Schwarz & M. Gallop).

Solid–phase Synthesis of Sequence–specific Phenylacetylene Oligomers (J. Moore, et al.).

Polymer–assisted Solution Phase Methods for Chemical Library Synthesis (D. Flynn, et al.).

Solid–phase Organic Synthesis on Radiation–grafted Polymer Surfaces: Application of SynPhase(TM) Crowns to Multiple Parallel Syntheses (I. James, et al.).

Vibrational Spectroscopy for Optimization of Solid–phase Organic Syntheses (B. Yan).

Recent Advances in Solid–phase Synthesis of Natural Products (L. Wilson).
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Kevin Burgess
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