Preparative Enantioselective Chromatography

  • ID: 2178567
  • Book
  • 344 Pages
  • John Wiley and Sons Ltd
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The development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale.

Written for chemists, chemical engineers and analytical chemists, Preparative Enantioselective Chromatography demonstrates the considerable utility of the technique in contemporary discovery, development and production scale chemistry. By briefly covering basic preparative chromatography then developing the discussion to cover chiral stationary phases for preparative use, method development and practical applications, the first part of this book serves as an ideal introduction to the technology for laboratory and pilot plant scale application. The more detailed information presented in the later chapters, on applications in discovery, process development and large scale or production environments, including case studies and equipment selection issues, ensures the book will serve as a sound reference for experienced separation scientists.

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Contributors.

Preface.

1. Chiral Chromatography in Support of Pharmaceutical Process Research (Christopher J. Welch).

2. Introduction to Preparative Chromatography (Geoffrey B. Cox).

3. Chiral Stationary Phases for Preparative Enantioselective Chromatography (Eric Francotte).

4. Method Development for Preparative Enantioselective Chromatography (Christina Suteu).

5. Scaling–Up of Preparative Chromatographic Enantiomer Separations (Jules Dingenen).

6. Steady–State Recycling and Its use in Chiral Separations (Charles M. Grill and Laurence M. Miller).

7. Simulated Moving Bed and Related Techniques (Luís S. Pais, Vera G. Mata and Alírio E. Rodrigues).

8. Preparative–Scale Supercritical Fluid Chromatography (Manon S. Villeneuve and Luke A. Miller).

9. Equipment for Preparative and Large Size Enantioselective Chromatography (Henri Colin, Olivier Ludemann–Hombourger and Félicie Denet).

10. Case Study in Production–Scale Multicolumn Continuous Chromatography (Michel Hamende).

11. Contract Manufacturing and Outsourcing Considerations (Olivier Dapremont).

Appendix: Advanced Concepts.

Index.

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Geoffrey B. Cox
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