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Heterocyclic Chemistry. 5th Edition

  • ID: 2178716
  • Book
  • 718 Pages
  • John Wiley and Sons Ltd
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Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.

Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second– and third–year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.

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Definitions of abbreviations

1. Heterocyclic nomenclature

2. Structures and spectroscopic properties of aromatic heterocycles

3. Substitutions of aromatic heterocycles

4. Organometallic heterocyclic chemistry

5. Methods in heterocyclic chemistry

6. Ring synthesis of aromatic heterocycles

7. Typical reactivity of pyridines, quinolines and isoquinolines

8. Pyridines: reactions and synthesis

9. Quinolines and isoquinolines: reactions and synthesis

10. Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones

11. Pyryliums, 2– and 4–pyrones: reactions and synthesis

12. Benzopyryliums, benzopyrones: reactions and synthesis

13. Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine

14. The diazines: pyridazine, pyrimidine, and pyrazine: reactions and synthesis

15. Typical reactivity of pyrroles, thiophenes, and furans

16. Pyrroles: reactions and synthesis

17. Thiophenes: reactions and synthesis

18. Furans: reactions and synthesis

19. Typical reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans

20. Indoles: reactions and synthesis

21. Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis

22. Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis

23. Typical reactivity of 1,3– and 1,2–azoles and benzo–1,3– and –1,2–azoles

24. 1,3–Azoles: imidazoles, thiazoles, and oxazoles: reactions and synthesis

25. 1,2–Azoles: pyrazoles, isothiazoles, isoxazoles: reactions and synthesis

26. Benzanellated azoles: reactions and synthesis

27. Purines: reactions and synthesis

28. Heterocycles containing a ring–junction nitrogen (bridgehead compounds)

29. Heterocycles containing more than two heteroatoms

30. Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis

31. Special topics

32. Heterocycles in biochemistry; heterocyclic natural products

33. Heterocycles in medicine

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John A. Joule
Keith Mills
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