This volume is part of a series of meetings held in Luxembourg to discuss therapeutic applications in the field of signal transduction, transcription, and translation. These meetings and the volumes comprising their proceedings have brought forward new insights in this rapidly moving field.
Chapters on hypoxia signal transduction, phosphoserine/threonine–binding domains, targeting of polycomb repressive complexes, conserved signaling mechanisms in innate immunity, and signal transduction by stress–activated MAP kinases have been provided by the keynote speakers at the meeting. Other topics included among these reports on recent research are receptor signaling, protein kinase cascades as therapeutic targets, cell death in cancer, inflammation–specific signaling, cell signaling pathways leading to regulated chromatin modifications, and transcriptional control.
Part A focuses on basic research, and the chapters are divided into the following sections: apoptotic cell signaling mechanisms, extracellular matrix interactions, and MAP kinases.
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1. Pleiotropic Effects of PI–3 Kinase/Akt Signaling in Human Hepatoma Cell Proliferation and Drug–Induced Apoptosis: Catherine Alexia, Marl`Ene Bras, Guillaume Fallot, Nathalie Vadrot, Fanny Daniel, Malika Lasfer, Houda Tamouza, and Andre Groyer.
2. Expression of Bcl–xL, Bax, and p53 in Primary Tumors and Lymph Node Metastases in Oral Squamous Cell Carcinoma: Marek Baltaziak, Ewa Duraj, Mariusz Koda, Andrzej Wincewicz, Marcin Musiatowicz, Luiza Kanczuga–Koda, Magdalena Szymanska, Tomasz Lesniewicz, and Boguslaw Musiatowicz.
3. Reactive Structural Dynamics of Synaptic Mitochondria in Ischemic Delayed Neuronal Death: Carlo Bertoni–Freddari, Patrizia Fattoretti, Tiziana Casoli, Giuseppina Di Stefano, Moreno Solazzi, Elisa Perna, and Clara De Angelis.
4. Selective Resistance of Tetraploid Cancer Cells against DNA Damage–Induced Apoptosis: Maria Castedo, Arnaud Coquelle, Ilio Vitale, Sonia Vivet, Shahul Mouhamad, Sophie Viaud, Laurence Zitvogel, and Guido Kroemer.
5. Molecular Determinants Involved in the Increase of Damage–Induced Apoptosis and Delay of Secondary Necrosis due to Inhibition of Mono(ADP–Ribosyl)ation: Claudia Cerella, Cristina Mearelli, Sergio Ammendola, Milena De Nicola, Maria D alessio, Andrea Magrini, Antonio Bergamaschi, and Lina Ghibelli.
6. Magnetic Fields Protect from Apoptosis via Redox Alteration: M. De Nicola, S. Cordisco, C. Cerella, M.C. Albertini, M. D alessio, A. Accorsi, A. Bergamaschi, A. Magrini, and L. Ghibelli.
7. The Cleavage Mode of Apoptotic Nuclear Vesiculation Is Related to Plasma Membrane Blebbing and Depends on Actin Reorganization: M. De Nicola, C. Cerella, M. D alessio, S. Coppola, A. Magrini, A. Bergamaschi, and L. Ghibelli.
8. Experimental Apoptosis Provides Clues about the Role of Mitochondrial Changes in Neuronal Death: Patrizia Fattoretti, Carlo Bertoni–Freddari, Rina Recchioni, Belinda Giorgetti, Marta Balietti, Yessica Grossi, Moreno Solazzi, Tiziana Casoli, Giuseppina Di Stefano, and Fiorella Marcheselli.
9. Alterations in mRNA Expression of Apoptosis–Related Genes BCL2, BAX, FAS, Caspase–3, and the Novel Member BCL2L12 after Treatment of Human Leukemic Cell Line HL60 with the Antineoplastic Agent Etoposide: Kostas V. Floros, Hellinida Thomadaki, Dimitra Florou, Maroulio Talieri, and Andreas Scorilas.
10. Using Janus Green B to Study Paraquat Toxicity in Rat Liver Mitochondria: Role of ACE Inhibitors (Thiol and Nonthiol ACEi): M. Ghazi–Khansari, A. Mohammadi–Bardbori, and M–J. Hosseini.
11. Membrane Fluidity Changes Are Associated with Benzo[a]Pyrene–Induced Apoptosis in F258 Cells: Protection by Exogenous Cholesterol: Morgane Gorria, Xavier Tekpli, Odile Sergent, Laurence Huc, Francois Gaboriau, Mary Rissel, Martine Chevanne, Marie–Therese Dimanche–Boitrel, and Dominique Lagadic–Gossmann.
12. Metal–Containing Proteins in the Apoptosis and Redox Processes in the Rat Prostate and Human Prostate Cells: I. Grbavac, C. Wolf, N. Wenda, D. Alber, M. Kuhbacher, D. Behne, and A. Kyriakopoulos.
13. Does Transduced p27 Induce Apoptosis in Human Tumor Cell Lines?: Mira Grdisa, Ana–Matea Mikecin, and Miroslav Poznic.
14. Apoptotic Cell Signaling in Lymphocytes from HIV+ Patients during Successful Therapy: Sandro Grelli, Emanuela Balestrieri, Claudia Matteucci, Antonella Minutolo, Gabriella D ettorre, Filippo Lauria, Francesco Montella, Vincenzo Vullo, Stefano Vella, Cartesio Favalli, Antonio Mastino, and Beatrice Macchi.
15. Capacitation and Acrosome Reaction in Nonapoptotic Human Spermatozoa: Sonja Grunewald, Thomas Baumann, Uwe Paasch, and Hans–Juergen Glander.
16. Caspase Activation and Extracellular Signal–Regulated Kinase/Akt Inhibition Were Involved in Luteolin–Induced Apoptosis in Lewis Lung Carcinoma Cells: Jin–Hyung Kim, Eun–Ok Lee, Hyo–Jung Lee, Jin–Sook Ku, Min–Ho Lee, Deok–Chun Yang, and Sung–Hoon Kim.
17. Ceramide Modulation of Antigen–Triggered Ca2+ Signals and Cell Fate: Diversity in the Responses of Various Immunocytes: Endre Kiss, Gabriella Sarmay, and Janos Matko.
18. Caspase–3 Activation, Bcl–2 Contents, and Soluble FAS–Ligand Are Not Related to the Inflammatory Marker Profile in Patients with Sepsis and Septic Shock: Fabian Kriebel, Silke Wittemann, Hsin–Yun Hsu, Thomas Joos, Manfred Weiss, and E. Marion Schneider.
19. Two Forms of the Nuclear Matrix Bound p53 Protein in HEK293 Cells: Maria A. Lapshina, Igor I. Parkhomenko, and Alexei A. Terentiev.
20. Jpk, a Novel Cell Death Inducer, Regulates the Expression of Hoxa7 in F9 Teratocarcinoma Cells, but not during Apoptosis: Eun Young Lee and Myoung Hee Kim.
21. HGF/SF Regulates Expression of Apoptotic Genes in MCF–10A Human Mammary Epithelial Cells: Catherine Leroy, Julien Deheuninck, Sylvie Reveneau, Benedicte Foveau, Zongling Ji, Celine Villenet, Sabine Quief, David Tulasne, Jean–Pierre Kerckaert, and Veronique Fafeur.
22. Arsenic Trioxide Represses NF–kB Activation and Increases Apoptosis in ATRA–Treated APL Cells: Julie Mathieu and Francoise Besancon.
23. Cytotoxicity of TRAIL/Anticancer Drug Combinations in Human Normal Cells: Olivier Meurette, Anne Fontaine, Amelie Rebillard, Gwenaelle Le Moigne, Thierry Lamy, Dominique Lagadic–Gossmann, and Marie–Therese Dimanche–Boitrel.
24. Hyperpolarization of Plasma Membrane of Tumor Cells Sensitive to Antiapoptotic Effects of Magnetic Fields: S. Nuccitelli, C. Cerella, S. Cordisco, M.C. Albertini, A. Accorsi, M. De Nicola, M. D alessio, F. Radogna, A. Magrini, A. Bergamaschi, and L. Ghibelli.
25. Melatonin as an Apoptosis Antagonist: Flavia Radogna, Laura Paternoster, Maria Cristina Albertini, Augusto Accorsi, Claudia Cerella, Maria D alessio, Milena De Nicola, Silvia Nuccitelli, Andrea Magrini, Antonio Bergamaschi, and Lina Ghibelli.
26. Prevention of p53 Degradation in Human MCF–7 Cells by Proteasome Inhibitors Does Not Mimic the Action of Roscovitine: Carmen Ranftler, Marieta Gueorguieva, and Jozefa Wesierska–Gadek.
27. Role of ATP in Trauma–Associated Cytokine Release and Apoptosis by P2X7 Ion Channel Stimulation: E. Marion Schneider, Katrin Vorlaender, Xueling Ma, Weidong Du, and Manfred Weiss.
28. Experimental Sepsis: Characteristics of Activated Macrophages and Apoptotic Cells in the Rat Spleen: Helle Evi Simovart, Andres Arend, Helle Tapfer, Kersti Kokk, Marina Aunapuu, Elle Poldoja, Gunnar Selstam, and Aade Liigant.
29. Insulin–Like Growth Factor–I Receptor Correlates with Connexin 26 and Bcl–xL Expression in Human Colorectal Cancer: Stanislaw Sulkowski, Luiza Kanczuga–Koda, Mariusz Koda, Andrzej Wincewicz, and Mariola Sulkowska.
30. Characterization of the Proapoptotic Intracellular Mechanisms Induced by a Toxic Conformer of the Recombinant Human Prion Protein Fragment 90 231: Valentina Villa, Alessandro Corsaro, Stefano Thellung, Domenico Paludi, Katia Chiovitti, Valentina Venezia, Mario Nizzari, Claudio Russo, Gennaro Schettini, Antonio Aceto, and Tullio Florio.
31. Role of NADPH Oxidase and Calcium in Cerulein–Induced Apoptosis: Involvement of Apoptosis–Inducing Factor: Ji Hoon Yu, Kyung Hwan Kim, and Hyeyoung Kim.
Part II: Extracellular Matrix Interactions:.
32. Signaling for Integrin a5 / b1 Expression in Helicobacter pylori Infected Gastric Epithelial AGS Cells: Soon Ok Cho, Kyung Hwan Kim, Joo–Heon Yoon, and Hyeyoung Kim.
33. Human Recombinant Vasostatin–1 May Interfere with Cell Extracellular Matrix Interactions: Valentina Di Felice, Francesco Cappello, Antonella Montalbano, Nella Ardizzone, Claudia Campanella, Angela De Luca, Daniela Amelio, Bruno Tota, Angelo Corti, and Giovanni Zummo.
34. Microgravity Signal Ensnarls Cell Adhesion, Cytoskeleton, and Matrix Proteins of Rat Osteoblasts: Osteopontin, CD44, Osteonectin, and a–Tubulin: Yasuhiro Kumei, Sadao Morita, Hisako Katano, Hideo Akiyama, Masahiko Hirano, Kei ichi Oyha, and Hitoyata Shimokawa.
35. 14–3–3 Proteins Bind Both Filamin and aLb2 Integrin in Activated T Cells: Susanna M. Nurmi, Carl G. Gahmberg, and Susanna C. Fagerholm.
36. Grb2–Associated Binder 1 (Gab1) Adaptor/Scaffolding Protein Regulates Erk Signal in Human B Cells: Adrienn Angyal, David Medgyesi, and Gabriella Sarmay.
37. CXC Receptor and Chemokine Expression in Human Meningioma: SDF1/CXCR4 Signaling Activates ERK1/2 and Stimulates Meningioma Cell Proliferation: Federica Barbieri, Adriana Bajetto, Carola Porcile, Alessandra Pattarozzi, Alessandro Massa, Gianluigi Lunardi, Gianluigi Zona, Alessandra Dorcaratto, Jean Louis Ravetti, Renato Spaziante, Gennaro Schettini, and Tullio Florio.
38. Reduction of Bcr–Abl Function Leads to Erythroid Differentiation of K562 Cells via Downregulation of ERK: A. Brozik, N.P. Casey, Cs. Hegedus, A. Bors, A. Kozma, H. Andrikovics, M. Geiszt, K. Nemet, and M. Magocsi.
39. The MAPK Pathway and HIF–1 Are Involved in the Induction of the Human PAI–1 Gene Expression by Insulin in the Human Hepatoma Cell Line HepG2: Elitsa Y. Dimova and Thomas Kietzmann.
40. Role of Mitogen–Activated Protein Kinases, NF–kB, and AP–1 on Cerulein–Induced IL–8 Expression in Pancreatic Acinar Cells: Kyung Don Ju, Ji Hoon Yu, Hyeyoung Kim, and Kyung Hwan Kim.
41. Upregulation of VEGF by 15–Deoxy– 12,14–Prostaglandin J2 via Heme Oxygenase–1 and ERK1/2 Signaling in MCF–7 Cells: Eun–Hee Kim, Hye–Kyung Na, and Young–Joon Surh.
42. SDF–1 Controls Pituitary Cell Proliferation through the Activation of ERK1/2 and the Ca2+–Dependent, Cytosolic Tyrosine Kinase Pyk2: Alessandro Massa, Silvia Casagrande, Adriana Bajetto, Carola Porcile, Federica Barbieri, Stefano Thellung, Sara Arena, Alessandra Pattarozzi, Monica Gatti, Alessandro Corsaro, Mauro Robello, Gennaro Schettini, and Tullio Florio.
43. Insulin Primes Human Neutrophils for CCL3–Induced Migration: Crucial Role for JNK 1/2: Fabrizio Montecucco, Giordano Bianchi, Maria Bertolotto, Giorgio Viviani, Franco Dallegri, and Luciano Ottonello.
44. Doxorubicin–Induced MAPK Activation in Hepatocyte Cultures Is Independent of Oxidant Damage: Rosaura Navarro, Rosa Mart nez, Idoia Busnadiego, M. Begona Ruiz–Larrea, and Jose Ignacio Ruiz–Sanz.
45. Superoxide Anions Are Involved in Doxorubicin–Induced ERK Activation in Hepatocyte Cultures: Rosaura Navarro, Idoia Busnadiego, M. Begona Ruiz–Larrea, and Jose Ignacio Ruiz–Sanz.
46. MAPKinase Gene Expression, as Determined by Microarray Analysis, Distinguishes Uncomplicated from Complicated Reconstitution after Major Surgical Trauma: E. Marion Schneider, Manfred Weiss, Weidong Du, Gerhard Leder, Klaus Buttenschon, Ulrich C. Liener, and Uwe B. Bruckner.
47. Effects of Chemical Ischemia on Cerebral Cortex Slices: Focus on Mitogen–Activated Protein Kinase Cascade: Anna Siniscalchi, Sabrina Cavallini, Silvia Marino, Sofia Falzarano, Lara Franceschetti, and Rita Selvatici.
48. Amyloid Precursor Protein Modulates ERK–1 and –2 Signaling: Valentina Venezia, Mario Nizzari, Emanuela Repetto, Elisabetta Violani, Alessandro Corsaro, Stefano Thellung, Valentina Villa, Pia Carlo, Gennaro Schettini, Tullio Florio, and Claudio Russo.
Index of Contributors