The first of two volumes, the volume comprises three sections: (1) insights into skeletal development, including, among others, novel ideas about the role of the perichondrium in skeletogenesis, current studies on joint formation, and the human consequences of dysregulated morphogenic signaling; (2) a traditional series of papers, both reviews and original research articles on bone cells osteoblasts, osteoclasts, and osteocytes in relation to mechanisms underlying their formation, fate, and function; and (3) new information on the role of hormones, both steroids and peptides, as well as cytokines and the central nervous system in regulating skeletal remodeling.
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Intracellular Protein Degradation: From a Vague Idea Through the Lysosome and the Ubiquitin–Proteasome System and onto Human Diseases and Drug Targeting: Aaron Ciechanover.
Part I: New Insights into Bone Development:.
1. Multiplicity of BMP Signaling in Skeletal Development: Xiangwei Wu , Weibin Shi , Xu Cao.
2. Nephroblastoma Overexpressed (NOV) Is A Novel Bone Morphogenetic Protein Antagonist: Ernesto Canalis.
3. The Role of the Perichondrium in Fetal Bone Development: Henry M. Kronenberg.
4. The PTHrP Functional Domain Is at the Gates of Endochondral Bones: Arthur E. Broadus, Carolyn Macica, Xuesong Chen.
5. Axin1 and Axin2 Are Regulated by TGF– and Mediate Crosstalk between TGF– and Wnt SignalingPathways: Debbie Y. Dao, Xue Yang, Di Chen, Michael Zuscik, and Regis J. O Keefe,.
6. Synovial Joint Formation during Mouse Limb Skeletogenesis: Roles of Indian Hedgehog Signaling: Eiki Koyama, Takanaga Ochiai, Ryan B. Rountree, Motomi Enomoto–Iwamoto, Masahiro Iwamoto, and Maurizio Pacifici.
7. Morphogen Receptor Genes and Metamorphogenes: Skeleton Keys to the Metamorphosis: Frederick S. Kaplan, Jay Groppe, Robert J. Pignolo, and Eileen M. Shore.
8. Differential Effects of IVEGF on Joint Formation During Liimb Development: Gloria Emelí Cortina–Ramírez and Jesús Chimal–Monroy.
9. Negative Regulation of Otic Capsule Chondrogenesis: It Can Make You Smad: Wei Liu, Sydney Butts, Harold Kim, Dorothy A. Frenz.
10. A Novel Transgenic Mouse Model to Study the Osteoblast lineage in vivo: Christa Maes, Tatsuya Kobayashi, Henry M. Kronenberg.
Part II: Formation, Function and Fate of Bone Cells:.
11. Balanced Regulation of Proliferation, Growth, Differentiation, and Degradation In Skeletal Cells: Harry C Blair, Li Sun, Ronald A Kohanski.
12. Control of Postnatal Bone Mass by the Zinc Finger Adapter Protein Schnurri–3: Laurie H. Glimcher , Dallas C. Jones, Marc N. Wein.
13. Suppression of PPAR– transactivation Switches Cell Fate of Bone Marrow Stem Cells from Adipocytes into Osteoblasts: Ichiro Takada, Miyuki Suzawa, Kunihiro Matsumoto, and Shigeaki Kato.
14. Transcriptional Regulation of Osteoblasts: Renny T. Franceschi, Chunxi Ge, Guozhi Xiao, Hernan Roca and Di Jiang.
15. Identification of Additional Dimerization Partners of FIAT, The Factor Inhibiting ATF4–mediated Transcription: René St–Arnaud and Bilal El Chaarani.
16. Cellular and Molecular Consequences of Calcineurin Aalpha Gene Deletion: Li Sun, Ling–Ling Zhu, Neeha Zaidi, Guozhe Yang, Baljit S. Moonga, Etsuko Abe, Jameel Iqbal, Solomon Epstein, Harry C. Blair, Christopher L.–H. Huang, Mone Zaidi.
17. The Role of NFAT in Osteoclast Formation: Hiroshi Takayanagi.
18. Mechanisms of Osteoclastic Secretion: Haibo Zhao and F. Patrick Ross.
19. New Roles for Osteoclasts in Bone: Brendan F. Boyce.
20. Similarities and Contrasts in Ryanodine Receptor Localization and Function in Osteoclasts and Striated Muscle Cells: Christopher L–H. Huang, Li Sun, James A. Fraser, Andrew A. Grace and Mone Zaidi.
21. Posttranslational Regulation of Bim by Caspase–3 in The Osteoclast: Hidetoshi Wakeyama, Toru Akiyama, Yuho Kadono, Masaki Nakamura, Yasushi Oshima, Kozo Nakamura and Sakae Tanaka.
22. Osteocytes as Dynamic, Multifunctional Cells: Lynda F Bonewald.
23. A Chromosomal Inversion within A Quantitative Trait Locus Has A Major Effect on Adipogenesis and Osteoblastogenesis: Cheryl L Ackert–Bicknella, Jesse L Salisburya, Mark Horowitz, Victoria E DeMambroa, Lindsay G Hortona, Kathryn L Shultz, Beata Lecka–Czernik , Clifford J Rosen.
24. Osteoblasts Cultured on Three–dimensional Synthetic Hydroxy–apatite Implanted on A Chick Allantochorial Membrane Induce Ectopic Bone Marrow Differentiation: Lucia Mancini, Roberto Tamma, Maria Settanni, Claudia Camerino, Nicola Patano, Giovanni Greco, Maurizio Strippoli and Alberta Zallone.
25. Trail is Involved in Human Osteoclast Apoptosis: Giacomina Brunetti, Angela Oranger, Giorgio Mori, Roberto Tamma, Adriana Di Benedetto, Paolo Pignataro, Felice R. Grassi, Alberta Zallone, Maria Grano, and Silvia Colucci.
26. Proteomic Analysis of Hydroxyapatite Interaction Proteins in Bone: Hai–Yan Zhou.
Part III: Regulation of Skeletal Remodeling:.
27. Nuclear Receptors and Bone: Ronald Margolis.
28. Glucocorticoids and the Osteoclast: Hyun–Ju Kim, Haibo Zhao, Hideki Kitaura, Sandip Bhattacharyya, Judson A. Brewer, Louis J. Muglia, F. Patrick Ross, Steven L. Teitelbaum.
29. Vitamin D: Molecular Mechanism of Action: Sylvia Christakos, Puneet Dhawan, Bryan Benn, Angela Porta, Matthias Hediger, Goo T. Oh, Yan Zhong, Dare Ajibade, Kopal Dhawan and Sneha Joshi.
30. Parathyroid hormone regulates histone deacetylases in osteoblasts: Emi Shimizu, Nagarajan Selvamurugan, Jennifer J. Westendorf, Nicola C. Partridge.
31. Parathyroid Hormone Stimulation of Non–Canonical Wnt Signaling in Bone: Marika K Bergenstock and Nicola C Partridge.
32. T cells: Unexpected Players in the Bone Loss Induced By Estrogen Ddficiency and in Basal Bone Homeostasis: M. Neale Weitzmann and Roberto Pacifici.
33. Pre–Resorptive Actions of FSH and Bone Loss: Mone Zaidi, Harry C. Blair, Jameel Iqbal, Ling Ling Zhu, T. Rajendra Kumar, Alberta Zallone and Li Sun.
34. Bone Loss in Thyroid Disease: Role of Low TSH and High Thyroid Hormone: Etsuko Abe, Li Sun, Jeffrey Mechanick, Jameel Iqbal, Kosj Yamoah, Ramkumarie Baliram, Ario Arabi, Baljit S. Moonga, Terry F. Davies and Mone Zaidi.
35. Hematopoietic Stem Cell Trafficking: Regulated Adhesion and Attraction to Bone Marrow Microenvironment: Simón Méndez–Ferrer and Paul S. Frenette.
36. Regulation of Skeletal Remodeling by the Endocannabinoid Sytem: Itai A. Bab.
37. Androgens Promote Preosteoblast Differentiation via Activation of the Canonical Wnt Signaling Pathway: Xin–Hua Liu , Alexander Kirschenbaum, Shen Yao, and Alice C. Levine.
38. Tumor Necrosis Factor Family Receptors Regulating Bone Turnover: New Observations in Osteoblastic and Osteoclastic Cell Lines: Lisa J Robinson, Christopher W Borysenko, and Harry C Blair.
39. Bone Loss After Temporarily Induced Muscle Paralysis by Botox is Not Filly Recovered After 12 weeks: Susan K. Grimston, Matthew J. Silva, Roberto Civitelli.
40. Genetics of Hypercalciuric Nephrolithiasis (Renal Dtone Disease): Michael J Stechman, Nellie Y Loh and Rajesh V Thakker.
41. Correlation Among Hyperphosphatemia, Type II Sodium–Phosphate Transporter Activity, and Vitamin D Metabolism in Fgf–23 Null Mice: Despina Sitara.
42. Osteoblast anOsteoclast Differentiation in Modeled Microgravity: Ritu Saxena, George Panb and Jay M. McDonald.
43. Evolution, Aging and Osteoporosis: Stephanie Tung and Jameel Iqbal