Thymosins in Health and Disease. Second International Symposium, Volume 1194. Annals of the New York Academy of Sciences

  • ID: 2178946
  • Book
  • Region: Global, New York
  • 300 Pages
  • John Wiley and Sons Ltd
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This volumes features contributions on the latest advances in the chemistry, biology and clinical applications of the thymosins from leading scientists and clinicians working in the field. The use of chemically defined and synthesized molecules, rather than crude or partially purified extracts has enabled scientists working in this field to acquire definitive information on the molecular biology, immunology and potential clinical applications of this important class of BRMs. 

Paper in this volume cover a wide range of topics including:

- advances  in the structure, design, immunology and molecular biology of thymosin alpha 1 (T 1), prothymosin alpha (ProT ) and thymosin beta 4 (T 4). 
- an exploration of role of the thymosins in cardioprotection, neuroplasticity, stem cells, wound healing, inflammation and angiogenesis
- clinical applications of T 1 and other BRMs
- a look at the current status of translational trials with T 4 in areas of wound repair, cardiovascular disease, epidermolysis bullosa and eye injuries.

The availability of synthetic thymosins enables both researchers and clinicians to acquire definitive information on the immunology, pharmacology and emerging clinical applications of T 1 and T 4.  Clinicians will be particularly interested in the most recent reports of clinical responses and diagnostic applications. 

This volume will also be of keen interest to biochemists, pharmacologists, immunologists and other basic scientists interested in acquiring information on the state of the art of the latest purification procedures, the chemical characterization, pharmacokinetics, immunopharmacology, and molecular biology of the thymosins alone or in combination with other BRMs and standard therapies.

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Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world–renowned authority on the thymus gland and the workings of the immune system, and co–discoverer of the thymosins.

Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience.

He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co–founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non–profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals.

Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.

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