Domino Reactions in Organic Synthesis

  • ID: 2179443
  • Book
  • 631 Pages
  • John Wiley and Sons Ltd
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The formation of complex molecules in only a few steps has always been a dream among chemists. That this is possible can be seen in nature, where complicated molecules such as palytoxin, maitotoxin and others are made in a highly efficient way. This dream has now almost become true for bench chemists with the development of domino reactions.

Domino reactions are the key to sequences of chemical transformations, which allow products to be synthesized in one–pot in a simple, efficient and elegant way without isolating any intermediates. Such reactions can not only be employed in basic research but also in applied chemistry and their use has a twofold advantage. On the one hand for industry, since the costs of labor, waste management, energy as well as chemicals decrease, and on the other hand their use is beneficial for our environment, since they help to save our natural resources and lighten the burden on our environment. It is therefore not surprising that this new concept has been rapidly adopted by the scientific community.

Containing over one thousand citations, this book covers novel reaction sequences right up to the middle of 2005 while also including important older work. Moreover, some recent work from as recently as 2006 is also discussed.

Written by the well–respected expert Professor Lutz Tietze and his students, Gordon Brasche and Kersten Gericke, who analyze the potential of this revolutionary concept, this is a definite must for every organic chemist at universities and research institutions, as well as those working in the chemicals industry.
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Introduction

Cationic domino reactions

Anionic domino reactions

Radical domino reactions

Pericyclic domino reactions

Photochemically induced domino processes

Transition metal catalysis

Domino reactions initiated by oxidation or reduction

Enzymes in domino reactions

Multicomponent reactions

Special techniques in domino reactions

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Lutz F. Tietze
Gordon Brasche
Kersten Gericke
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