Bioorganic Chemistry. Highlights and New Aspects

  • ID: 2179455
  • Book
  • 456 Pages
  • John Wiley and Sons Ltd
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Bioorganic Chemistry Highlights and New Aspects Edited by U. Diederichsen, T.K. Lindhorst, B. Westermann, and L.A. Wessjohann The understanding of (patho) physiological processes — the biosynthesis enzymes, nucleic acids, and secondary metabolites; the pathways of signaltransduction or the function of pharmaceutical agents — is of increasing importance not only in drug research but also for the development of new synthetic methods in organic chemistry and biochemistry. In a truly interdisciplinary way, bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, and organic chemistry. This book fills a void in this rapidly growing field of chemistry and gives a thorough yet understandable introduction for advanced students and researches alike. Contributions of more than sixty scientists provide a topical overview of recent advances in drug development based on natural products; the biosynthesis, activity, and application of enzymes; carbohydrates; peptides; nucleic acids, and analytical methods in bioorganic chemistry. This book will be an appetizer for all — students and researchers alike — seeking orientation in this fascinating field of chemistry.
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DRUGS AND SEARCH FOR LEAD STRUCTURES

Marine Alkaloids

Leukotriene Derivates

Diazoketones for the Synthesis of Beta–Lactams

Selenium Compounds in Biochemical Oxidations

Galaktophingolipid, etc

ENZYMOLOGY

Enzyme Catalyzed Diels–Alder Reactions

Enzymatic Halogenation in Bacteria

Biotransformations in the Stereoselective Synthesis of Cyclophanes, etc

CARBOHYDRATES

Mannosid Clusters

Glycoconjugates in Cancer Therapy, etc

PEPTIDES

Cyclodepsipeptides

Synthetic Adrenaline and Peptide Receptors

Substituted and Beta–Amino Acids as Building Blocks for Peptide Mimetics

Carbohydrate–Protein Interactions, etc.

NUCLEIC ACIDS

Reparing Dna

In Vitro Selection

Studies on Hairpin Ribozymes

New Pna Buiding Block for Antisense Research, etc.

BIOCHEMISTRY

Activity of Neuropeptide Y

Oligosaccharide Antibiotics

Biosynthesis of Plant Xanthones

Manipulating Intracellular Signal Transductions

Methyl–Transfer Reactions, etc.

SYNTHETIC AND ANALYTICAL METHODS

Constitutional Assignment of Marine Natural Products

Radical Induced Reactions in Biological Systems

Multivariate Analysis of Biotransformations, etc.
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Ulf Diederichsen
Thisbe K. Lindhorst
B. Westermann
Ludger A. Wessjohann
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