Carbohydrate-based Drug Discovery. 2 Volume Set

  • ID: 2179519
  • Book
  • 980 Pages
  • John Wiley and Sons Ltd
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Carbohydrates play a central role in metabolism, cell–cell recognition, and pathogen defense. To exploit the full potential of this diverse compound class for the development of pharmaceutically active substances, this handbook brings together the latest in carbohydrate chemistry with recent knowledge on the biological function of carbohydrates and their derivatives.

Particular emphasis is placed on carbohydrates with pharmaceutical potential, including the most promising carbohydrate–based therapies currently available.

From the Contents:

∗ Complex Carbohydrate Synthesis

∗ Solid–Phase Carbohydrate Synthesis

∗ Glycopeptides and Glycoproteins

∗ Synthetic Carbohydrate–based Vaccines and Antibiotics

∗ Carbohydrate Mimetics

∗ Sequencing of Oligosaccharides and Glycoproteins

∗ Carbohydrate Microarrays

∗ Multivalent Carbohydrate Ligands

∗ Glycosylated Natural Products

∗ Glycosyltransferase Inhibitors

∗ Sulfotransferase Inhibitors

∗ Carbohydrate–based Treatment of Cancer

∗ N–Acetylneuraminic Acid Derivatives as Anti–influenza Agents

∗ Aminoglycosides and Macrolides in RNA Recognition

A premier resource for carbohydrate chemists and drug developers, this comprehensive two–volume handbook contains contributions by more than 80 leading carbohydrate chemists.
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Complex Carbohydrate Synthesis

The Chemistry of Sialic Acid

Solid–Phase Oligosaccharide Synthesis

Solution and Polymer–supported Synthesis of Carbohydrates

Enzymatic Synthesis of Oligosaccharides

Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology

Chemistry and Biochemistry of Asparagine–linked Protein Glycosylation

Conformational Analysis of C–Glycosides and Related Compounds

Synthetic Lipid A Analogs for Sepsis Treatment

Polysialic Acid Vaccines

Synthetic Carbohydrate–based Vaccines

Antithrombotics Based on Synthetic Oligosaccharides

Sequencing of Oligosaccharides and Glycoproteins

Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans

Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes

Glycosyltransferase Inhibitors

RNA–Aminoglycoside Interactions

Glycosylated Natural Products

Small Molecule Inhibitors of the Sulfotransferases

Carbohydrate–based Treatment of Cancer Metastasis

N–Acetylneuraminic Acid Derivatives and Mimetics as Anti–influenza Agents

Carbohydrate–based Drug Discovery in the Battle Against Bacterial Infections

(partial contents)
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"In summary, Carbohydrate–Based Drug Discovery Vols. 1 and 2 provide an appropriate and useful look at the current state of the art in this relevant and rapidly advancing field. I recommend the book to both experts and less expert readers."

Francesco Nicotra, Università di Milano–Bicocca (Italy)

ChemBioChem 4/2004

"To summarize, the work provides a comprehensive and excellent survey of the present situation in carbohydrate research, in which many interesting details can be spotted. Because of the wide range of topics covered, the reader will refer to it again and again. It is likely to become a standard work on the subject, not exclusively for carbohydrate chemistry enthusiasts."

Oliver Plettenburg, Ulrich Stilz

Angewandte Chemie + IE 2004–43/31
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