This long–awaited book by M. A. Sierra and M. C. de la Torre fills just such a gap. Using major total syntheses they explain the most varied problems and recommend ways out of such dilemmas: Problems at the start and end of a synthesis, difficult and unexpected reactivities of functional groups, problems due to steric properties and much more.
The result is a true wealth of information for any organic chemist. The essential tool for successful total synthesis.
Chapter 1: Introduction: From the Paper to the Laboratory.
Chapter 2: Tuning–up, Tactical and Strategic Changes.
2.1 Tuning–up Reaction Conditions.
2.2 Tactical Changes.
2.3 Strategic Changes.
Chapter 3: Working with Models.
3.3 (+)–Damavaricin D.
3.4 Dynemicin A.
Chapter 4: The Unexpected Reactivity or Inertia of Common Functional Groups.
4.2 Octalactins A and B.
4.3 (–)–Polycavernoside A.
Chapter 5: The Influence of Remote Substituents.
5.1 "Alive" Dead Steric Volume.
5.2 The Reactive Remote Group.
Chapter 6: The Elusive Side Chain.
6.1 (±)–Scopadulcic Acid B.
Chapter 7: The Unpredictable Stereochemistry.
7.1 Nocardiones A and B.
7.3 Hamigerans A and B.
7.4 Calphostin A.
7.5 Fragment C3–C10 of Cytovaricin.
Chapter 8: Reluctant Ring Closures.
8.1 Discorhabdin C.
8.2 Discorhabdin A.
8.3 Frondosin B.
8.6 Roseophilin Tricyclic Core: The Formal Total Synthesis of Roseophilin.