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Biology of Depression

  • ID: 2179549
  • Book
  • 1095 Pages
  • John Wiley and Sons Ltd
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Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.
This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.
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Classification of Depression: Research and Diagnostic Criteria -
DSM-IV and ICD-10
Psychosocial and Environmental Formulations of Depression
The Economic Burden of Depression: Societal and Patient Perspectives
The Spectrum of Depressive Disorder
The Monoamine Theory of Depression
Monoaminergic-based Pharmacotherapy
Lessons of ECT, ICT and Psychosurgery: The Essential Nature of the Centrencephalic Seizure
Current Prognosis of Depression
Treatment of Depression in Medical Illness
Depression and Suicidality in Children and Adolescents
The Biology and Genetics of Suicidality
Geriatric Depression
Co-morbidity of Depression and Substance Abuse
Depression in the Context of Cancer
Treatment of Refractory Patients
Clinical Pharmacology of new classes of antidepressant drugs
Brain Imaging in Depression and Neuropathological Findings
Dysregulation of Circadian Rhythms in Depression: Molecular Mechanisms
Neuropeptidergic Dysfunction in Depression
Depression, Mania, and Thyroid Function: A Story of Intimate Relationships
Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities
Neuroimmune Mediators
Borna Disease Virus
Depression and Heart Disease
Metabolic Consequences of Depression
Genetic Substrates Shared by Depression and Cardiovascular Disease
Antidepressants and suicide: Clinical considerations
Animal Models of Depression
Loss and Deprivation: From Animal Models to Clinical Presentation
Genomics and Depression
Genetic Approaches to Depression: Linkage Studies
Genetic Approaches to Depression: Association Studies
Molecular Effects of Antidepressant Treatment
The Role of Transcription Factors in the Biology of Depression
Pharmacogenetics and Pharmacogenomics of antidepressant drug action
Pharmacogenetics of antidepressant drug metabolism
Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response
Emerging New Treatments
Complementary and Alternative Medicine treatment for Depression
History and Epidemiology of Depression
Depression in Developing Countries
The Experience of Depression
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Julio Licinio
Ma–Li Wong
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