Standards of Mouse Model Phenotyping

  • ID: 2179581
  • Book
  • 358 Pages
  • John Wiley and Sons Ltd
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This is the first book in the field of mouse genetics describing comprehensive and standardized methods for the characterization of laboratory mice. It provides a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, it is focused on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.
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Introduction

Generation of mouse models

PHENOTYPING AREAS

Endocrinologic anomalies

Metabolic analysis

Neurologic disorders

Immunology/Allergy

Lung function

Nociceptive features

Eye disorders

Molecular phenotyping

Cardio–vascular disorders

Host–pathogen interactions

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Dr Hrabe de Angelis is Director if theInstitute of Experimental Genetics, in Munich, Germany and Director of the European Mouse Mutant Archive (EMMA), in Monterotondo, Italy. He is also cofounder of "INGENIUM Biopharmaceuticals AG".

Processor Pierre Chambon is the director of the Institute of Genetics, Molecular and Cell Biology in Strasbourg. He has won numerous scientific prizes including the CNRS Gold Medal and the Grand Prix of the Foundation of Medical Reseach.

Professor Steve Brown is Director of the Mammalian Genetics Unit of the MRC in Harwell, UK, and is a member of EMBO.

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