Backed by the expertise of the world′s leading protein degradation experts, this handy reference compiles information on the proteasome–mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, latest results on novel members of the ubiquitin superfamily and their role in cellular regulation are presented here.
Further volumes in the series cover the function of ubiquitin–protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
The proteasome portal and regulation of proteolysis
PAN and the proteasome
Ubiquitin domain proteins
MEKK1: dual function as a protein kinase and a ubiquitin protein ligase
HECT domain ubiquitin protein ligases
UCRP: ubiquitin cross–reactive protein
SUMOs and their function in the cell
Functions of the ubiquitin–proteasome pathway
Molecular Chaperones and the ubiquitin/proteasome system
Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes
Electron microscopy of compartmentalised proteases
Molecular dissection of autophagy in yeast
"The series – when completed – is likely to become a comprehensive work of reference on the ubiquitin/proteasome system."