The Ubiquitin-Proteasome System. Volume 2. Protein Degradation - Product Image

The Ubiquitin-Proteasome System. Volume 2. Protein Degradation

  • ID: 2179602
  • Book
  • 300 Pages
  • John Wiley and Sons Ltd
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The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.

Backed by the expertise of the world′s leading protein degradation experts, this handy reference compiles information on the proteasome–mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, latest results on novel members of the ubiquitin superfamily and their role in cellular regulation are presented here.

Further volumes in the series cover the function of ubiquitin–protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.

Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

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Degrons: signals and sites for ubiquitylation

The proteasome portal and regulation of proteolysis

PAN and the proteasome

Ubiquitin domain proteins

MEKK1: dual function as a protein kinase and a ubiquitin protein ligase

HECT domain ubiquitin protein ligases

UCRP: ubiquitin cross–reactive protein

SUMOs and their function in the cell

Functions of the ubiquitin–proteasome pathway

Molecular Chaperones and the ubiquitin/proteasome system

Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes

Electron microscopy of compartmentalised proteases

Molecular dissection of autophagy in yeast

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"... a comprehensive chapter on the structure of large, self–compartmentalizing proteases ... gives an overview how complex these ′molecular machines′ are that keep our cells clean. The individual chapters are followed by extensive references, and this will quarantee immediate guided access to the important literature. In summary, the book provides much more than anyone could assemble from Pubmed in a meaningful way to get informed appropriately."

Zellbiologie aktuell

"The series – when completed – is likely to become a comprehensive work of reference on the ubiquitin/proteasome system."

ChemBioChem

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