Modern Biopharmaceuticals. Design, Development and Optimization 4 Volume Set

  • ID: 2179613
  • Book
  • 2022 Pages
  • John Wiley and Sons Ltd
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The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world, including nine blockbuster drugs, and nowadays represent the mainstay products of the biotechnology industry.

This book is unique in introducing readers to a comprehensive set of recently developed technologies, showing paradigm shifts in the health care system and reflecting these changes in industrial research.

Here, the world′s top scientists and business leaders divulge their first–hand expertise, allowing you to participate in their recent achievements. They all have their own specific contribution and have been carefully selected to provide a multifaceted and unique insight. Never before has such an impressive group of individuals contributed to one biotechnology book, including Nobel laureates Robert Huber and Thomas R. Cech, as well as authors from the world′s most famous academic institutes and biotech companies, such as ETH Zurich, MIT, Stanford, Yale, Princeton, Harvard Medical School, Max–Planck–Institute, Fraunhofer–Institute, Moscow Academy of Sciences, London Imperial College and Baxter, Invitrogen, MorphoSys, Roche, and Schering AG.

The result is a testament to the importance of biotechnology in life science, a sure sign that "Modern Biopharmaceuticals" will fuel biotechnologies and help shape the industry of the future.

For pharmaceutists, pharmaceutical chemists, biochemists, molecular biologists, medicinal chemists, as well as those working in the biotechnological and pharmaceutical industries, or biotechnological institutes.
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Volume 1

INTRODUCTION

PART I: BIOPHARMACEUTICALS USED IN MOLECULAR MEDICINE

Genes & genomes – correlation between genes, diseases & biopharmaceuticals

siRNA – the magic bullet & other gene therapeutical approaches

Mobilis in mobile – human embryonic stem cells & other sources for cell therapy

Volume 2

PART II: BIOPHARMACEUTICALS AND THEIR MODE OF ACTION

The clotting cascade – lysis, coagulation & a fine–tuned balance

Errare humanum est – what causes cancer & how to selectively fight tumors

Mundus vult decipi – high mutation rates of HIV & new paradigms for treatment

PART III: IMPROVING THE DEVELOPMENT OF BIOPHARMACEUTICALS

Citius, altius, fortius – acceleration by high throughput & ultra–HT

Early target validation – knock–out mice & more

Revolution by evolution – rational design for desire & the scientific art of optimization

Volume 3

PART IV: PRODUCTION OF BIOPHARMACEUTICALS

The industry′s workhorses – mammalian expression systems

A ripe and blooming market – biopharmaceuticals from transgenic animals & plants

Alea non iacta est – improving established expression systems

When success raises its ugly head – outsourcing to uncork the capacity bottleneck

PART V: BIOPHARMACEUTICALS USED FOR DIAGNOSTICS AND IMAGING

From hunter to craftsman – engineering antibodies with nature′s universal toolbox

Find, fight & follow – target–specific troica from Mother Nature′s Pharmacopoiea

Getting insight – sense the urgency for early diagnostics

Volume 4

PART VI: ADVANCED APPLICATION ROUTES FOR BIOPHARMACEUTICALS

Getting inside – quest for the best & how to improve delivery

Pathfinder – new ways for peptides, proteins & Co

Via mala – the stony road of DNA delivery: back–pack, feed–back & pay–back

Getting beyond – rocket science & science fiction

PART VII: FROM TRANSCRIPTION TO PRESCRIPTION

Opening the therapeutic window – between systemic toxicity & lack of efficacy

Happy end – claim to fame & approval

PART VIII: FROM BENCH TO BEDSIDE –

THE AFTERMATHS

Think big & dealmaking for growth – global changes in the health–care sector

News & views – quo vadis, biopharmaceuticals?

Small molecules – light at the end of the tunnel or back to the roots?
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Jörg Knäblein
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