This third volume in the series discusses the role of ubiquitin–mediated protein breakdown in cellular regulation and physiology.
Drawing on the combined knowledge of the world′s leading protein degradation experts, this handy reference includes information on
∗ deubiquitylating enzymes
∗ tyrosine kinase receptors
∗ the COP9/signalosome complex
∗ regulation of the NFKB system
∗ ubiquitin in transcription, DNA monitoring and repair, and peroxisomes,
∗ endocytosis and membrane trafficking
∗ the ubiquitin–proteasome system in plants and muscle development.
Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.
The ubiquitin–proteasome system and muscle development
The COP9 signalosome: structural and biochemical conservation and its roles in the regulation of plant development
Ubiquitin and protein sorting to the lysosome
The role of the ubiquitin proteasome pathway in the regulation of the cellular hypoxia response
p97 and ubiquitin: A complex story
Cdc48 (p97) and its co–factors
Deubiquitylating enzymes, cell proliferation, and cancer