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Mass Spectrometry in Medicinal Chemistry. Applications in Drug Discovery. Edition No. 1. Methods & Principles in Medicinal Chemistry

  • ID: 2179685
  • Book
  • February 2007
  • 460 Pages
  • John Wiley and Sons Ltd
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory.
Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
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Mass Spectrometry in Bioanalysis -
Methods, Principles and Instrumentation
Drug Screening Using Gel Permeation Chromatography Spin Columns Coupled with ESI-MS
ALIS: An Affinity Selection-Mass Spectrometry System for the Discovery and Characterization of Protein-Ligand Interactions
Library Screening Using Ultrafiltration and Mass Spectrometry
Continuous-Flow Systems for Ligand Binding and Enzyme Inhibition Assays Based on Mass Spectrometry
Frontal Affinity Chromatography -
Mass Spectrometry for Ligand Discovery and Characterization
MS-Binding Assays - an Alternative to Radioligand Binding
Laser Desorption Assays -
MALDI-MS, DIOS-MS, and SAMDI-MS
Tethering: Fragment-Based Drug Discovery by Mass Spectrometry
Interrogation of Noncovalent Complexes by ESI-MS: A Powerful Platform for High Throughput Drug Discovery
Quantification of Protein-Ligand Interactions in Solution by H/D Exchange (PLIMSTEX)
Protein-Targeting Drug Discovery Guided by Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)
Mass Spectrometry in Early Pharmacokinetic Investigations
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Klaus Wanner University of Munich, Germany.

Georg Höfner University of Munich, Germany.
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