Peptides. Chemistry and Biology. 2nd Edition

  • ID: 2179787
  • Book
  • 594 Pages
  • John Wiley and Sons Ltd
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With peptides playing such a valuable role in the body, the need for a modern and scientifically up–to–date advanced textbook is critical for both students and teachers. This book on peptide science distils the knowledge of hundreds of publications into a highly readable synopsis of this diverse field.

Commencing with the broad fundamentals of peptide synthesis and structure, systematic explanations of the important families of biologically active peptides are given, and the interdisciplinary approach covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, combinatorial synthesis, and proteomics.

This new edition has been fully revised and now features study questions and exercises for each learning unit, didactically enhanced for easier self–study and classroom teaching.

Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than 120 publications and together with Hans–Dieter Jakubke, has written the book Peptides from A – Z, also published by Wiley–VCH.

Hans–Dieter Jakubke studied Chemistry at the Martin–Luther–University Halle–Wittenberg, Germany. After finishing his PhD and postdoctoral work with Josef Rudinger in Prague (Czeck Republic), he was appointed Assistant Professor at the Department of Biochemistry in Halle, and Full Professor of Biochemistry at the University of Leipzig in 1977. He was director of the Department of Biochemistry from 1993–1997 and member of the Council of the European Peptide Society from 1990–1994. He authored several textbooks and encyclopedias on various aspects of chemistry and biochemistry including peptide research.
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INTRODUCTION AND BACKGROUND

FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES

Definitions and Main Conformational Features of the Peptide Bond

Building Blocks, Classification, and Nomenclature

Analysis of the Covalent Structure of Peptides and Proteins

Three–Dimensional Structure

Methods of Structural Analysis

BIOLOGY OF PEPTIDES

Historical Aspects and Biological Functions

Biosynthesis

Selected Biologically Active Peptides

PEPTIDE SYNTHESIS

Principles and Objectives

Protection of Functional Groups

Peptide Bond Formation

Racemization During Synthesis

Solid–Phase Peptide Synthesis (SPPS)

Biochemical Synthesis

SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS

Strategy and Tactics

Solution Phase Synthesis (SPS)

NEW: Solution Phase/Solid Phase–Hybrid Approaches

Optimized Strategies on Polymeric Support

Chemical Ligation Strategies

SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES

Cyclopeptides

Cystine Peptides

Glycopeptides

Phosphopeptides

Lipopeptides

Sulfated Peptides

PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS

Peptide Design

Modified Peptides

Peptidomimetics

Pseudobiopolymers

Macropeptides and De–Novo Design of Peptides and Proteins

COMBINATORIAL PEPTIDE SYNTHESIS

Parallel Synthesis

Synthesis of Mixtures

APPLICATION OF PEPTIDES AND PROTEINS

NEW: General Production Strategies

NEW: Improvement of the Therapeutic Potential

Protein Pharmaceuticals

Peptide Pharmaceuticals

PEPTIDES IN PROTEOMICS

NEW: Genome and Proteome

NEW: Separation Methods

NEW: Peptide and Protein Analysis in Proteomics

NEW: Activity–Based Proteomics

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Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than 120 publications and together with Hans–Dieter Jakubke, has written the book Peptides from A – Z, also published by Wiley–VCH.

Hans–Dieter Jakubke studied Chemistry at the Martin–Luther–University Halle–Wittenberg, Germany. After finishing his PhD and postdoctoral work with Josef Rudinger in Prague (Czeck Republic), he was appointed Assistant Professor at the Department of Biochemistry in Halle, and Full Professor of Biochemistry at the University of Leipzig in 1977. He was director of the Department of Biochemistry from 1993–1997 and member of the Council of the European Peptide Society from 1990–1994. He authored several textbooks and encyclopedias on various aspects of chemistry and biochemistry including peptide research.

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