Nuclear Receptors as Drug Targets, Volume 39. Methods and Principles in Medicinal Chemistry

  • ID: 2179792
  • Book
  • 522 Pages
  • John Wiley and Sons Ltd
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Nuclear receptors are the site of action for some of the most widely used medications, namely oral contraceptives and related drugs derived from steroid hormones. Recent research has uncovered their pivotal role in a range of human diseases, including diabetes and metabolic syndrome, triggering a new wave of drug discovery efforts focused on this class of molecular targets.

Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone–derived drugs, this handbook systematically treats the drug development aspects of all human nuclear receptors, including such recently characterized receptors as PPAR, FXR and LXR, and modern tools for nuclear receptor research.

With its contributions from authors working at leading pharmaceutical companies around the world providing examples and real–life data from their own experience, this is an invaluable reference for medicinal chemists, biochemists, molecular biologists, pharmacologists and those working in the pharmaceutical industry.
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Nuclear Receptors as Modern Drug Targets – a Historic Perspective

Targeting the Nuclear Receptor –

Cofactor Interaction

Untangling the Estrogen Receptor Web

Subtype Selective Estrogens

Estrogen Receptors as Therapeutic Targets in Breast Cancer

Progesterone Receptor and Progestines

Progesterone Receptor Antagonists

Nonsteroidal Tissue Selective Androgen Receptor Modulators

The Glucocorticoid Receptor as Target for Classic and Novel Anti–inflammatory Therapy and Novel Glucocorticoid Receptor Ligands

Vitamin D Analogs as Modulators of Vitamin D Receptor Action

PPARs: Therapeutic Targets for Metabolic Disease and Type 2 Diabetes

Retinoids in Clinical Use

Nuclear Receptors as Targets in Cardiovascular Diseases

NURR77 Family of Nuclear Receptors and its Modulators

Induction of Drug Metabolism: The Role of Nuclear Receptors

Nuclear Receptor Targeted Screening Libraries and Chemogenomics Approaches

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"With increasing importance attributed to this area, the text is a welcome review of the current field.... The quality of the text is good with very readable chapters and many useful original literature references. The book will be clearly valuable for both academic and industrial groups engaged in drug discovery." (Journal of Medicinal Chemistry, March 2009)

"This is an excellent book for scientists interested in adding or expanding expertise in nuclear receptor drug discovery to their skill set. The chapters are timely, well referenced into the 2008 literature, and focused on the chemistry of successful and emerging therapeutic small molecules." (Journal of the American Chemical Society, March 10, 2009)

"The book is a good reference for medicinal chemists, pharmacologists and those working in the pharmaceutical industry." (RoSearch, December 2008)

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