Tumor Angiogenesis

  • ID: 2179864
  • Book
  • 351 Pages
  • John Wiley and Sons Ltd
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Covering one of the most important research topics in cancer biology, this is an ideal ready reference for oncologists, cell biologists, pharmaceutists, pathologists, molecular biologists, internists, and researchers working in the pharmaceutical industry.

Following an introduction that provides an overview of tumor angiogenesis, the book goes on to look at mechanisms of angiogenesis and lymphangiogenesis, signal transduction, therapeutic approaches in combination with established treatments, and concludes with a section on imaging and biomarkers in angiogenesis.
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INTRODUCTION

Overview on Tumor Angiogenesis (Donati, Lorenzet)

MECHANISMS OF ANGIOGENESIS AND LYMPHANGIOGENESIS

Molecular Mechanisms of Angiogenesis (Dudley, Claesson–Welsh)

Pro–angiogenic Factors (Ribatti)

The Role of Accessory Cells in Tumor Angiogenesis (Takakura)

Comparison between Developmental and Tumor Angiogenesis (Bikfalvi)

Tumor Lymphangiogenesis (Ramu, Hong)

SIGNAL TRANSDUCTION AND ANGIOGENESIS

Integrin Involvement in Angiogenesis (Akalu, Contois, Brooks)

Signaling Pathways in Tumor Angiogenesis (Abrahams, Daly, Eichten, Li, Noguera–Troise, Thurston)

THERAPEUTIC APPROACHES AND ANGIOGENESIS

Development of an Integrin Targeted Anti–Angiogenic Agent (Swenson, Minea, Markland)

Anti–VEGF Approaches and Newer Antiangiogenic Agents (including combrestatins) which are already in Clinical (Libutti)

Combination of Antiagiogenic Therapy with Other Anticancer Therapies (Gasparini)

Tumor specificity of anti–angiogenic agents (Rixe, Kelly, Giaccone)

IMAGING AND BIOMARKERS IN ANGIOGENESIS

In vivo imaging of tumor angiogenesis (Turkbey, Ravizzini, Choyke)

Identifying Biomarkers to Establish Drug Efficacy (Platero)
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Francis S. Markland
Stephen Swenson
Radu Minea
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