Cellular and Biomolecular Recognition

  • ID: 2179888
  • Book
  • 368 Pages
  • John Wiley and Sons Ltd
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With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine.

The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.

From the contents:

∗ Chiral Molecular Imprinting as a Tool for Drug Sensing

∗ Biomimetic Nanoparticles Providing Molecularly Defined Recognition Sites

∗ Development of Functional Materials from Rod–Like Bionanoparticles

∗ Interaction Between Silica Particles and Human Epethelial Cells

∗ Multivalent Synthetic Receptors for Biomacromolecules

∗ Catalytic Antibodies for Selective Chemotherapy

∗ Natural and Synthetic Activators of the Immune Response

∗ Membrane–Active Natural and Synthetic Peptides and Peptidomimetics

∗ Imaging and Spectroscopic Analyses of Biomolecules and Biological Interactions Using Fluorescence and Colorimetric Methods, Atomic Force Microscopy, Surface Plasmon Resonance, and more.
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DEVELOPMENT OF FUNCTIONAL MATERIALS FROM ROD–LIKE VIRUSES

Introduction

Overview

Programmable Protein Shells

Templated Syntheses of Composite Materials

Self–Assembly of Rod–Like Viruses

Virus–Based Device and Applications

Outlook

BIOMIMETIC NANOPARTICLES PROVIDING MOLECULARLY DEFINED BINDING SITES –

PROTEIN–FEATURING STRUCTURES VERSUS MOLECULARLY IMPRINTED POLYMERS

Introduction

Core Materials and Functionalities

Functional Shells

Applications

Products

Conclusions

INTERACTION BETWEEN SILICA PARTICLES AND HUMAN EPITHELIAL CELLS: ATOMIC FORCE MICROSCOPY AND FLUORESCENCE STUDY

Interaction of Silica with Biological Cells: Background

Interaction of Silica Particle with the Cell Surface: How it is Seen with AFM

Ultra–Bright Fluorescent Silica Particles to be Used to Study Interaction with Cells

Ultra–Bright Fluorescent Silica Particles to Distinguish Between Cancer and Normal Cells

CHIRAL MOLECULAR IMPRINTING AS A TOOL FOR DRUG SENSING

Introduction

Electrochemical Drug Sensors

Optical Drug Sensors

Mass Drug Sensors

CATALYTIC ANTIBODIES FOR SELECTIVE CANCER CHEMOTHERAPY

Introduction

Catalytic Antibodies Designed for Prodrug Activation

Catalytic Antibody 38C2 and Cancer Therapy

Chemically Programmed Antibodies

NATURAL AND SYNTHETIC STIMULATORS OF THE IMMUNE RESPONSE

Introduction

Lipopolysaccharide Endotoxin –

A Potent Immunostimulatory Molecule

LPS Recognition

Septic Shock

LPS Biosynthesis

Minimal Modified Lipid A

Isolation of "Natural" Kdo2–Lipid A

Synthetic LPS, Lipid A and Their Uses

Structural Studies

Bacterial LPS–Binding Proteins

Sphingolipids –

Essential Membrane Components of Mammals, Plants, Fungi, Yeast and Bacteria

Natural Killer T Cells and GSLs

GSL Antigens

Structure –

Activity Relationships

Saccharide Modification

Ceramide Modification

High–Resolution Structural Analysis of Receptor–GSL Complexes

SUPRAMOLECULAR ASSEMBLIES OF POLYDIACETYLENES FOR BIOMOLECULAR SENSING: COLORIMETRIC AND "TURN–ON" FLUORESCENCE APPROACHES

Introduction

Vesicular PDA Sensors for Colorimetric Signaling of Bacterial Pore–Forming Toxin

Fabrication of "Turn–On" Fluorescence Vesicle Sensors with PDAs

"Mix–and–Detect" Type of "Turn–On" Fluorescence Sensor for Bacterial Toxin

MULTIVALENT SYNTHETIC RECEPTORS FOR PROTEINS

Aminopyrazoles for Beta–Sheet Capping in Protein Misfolding Events

New Mechanisms of Enzyme Inhibition by Molecular Clips and Tweezers

Protein Surface Recognition by Tailor–Made Polymers

ANALYSIS OF BIOLOGICAL INTERACTIONS AND RECOGNITIONS BY SURFACE PLASMON RESONANCE

Introduction to Surface Plasmon Resonance Technology

Working Principle of SPR

Sensor Surface Chemistry and Its Fabrications

Important Factors Impacting on the Performance of SPR–Based Analyses of Biological Interactions on the Nonbiological Transducer Surface

Localized SPR of Inorganic Nanoparticles for Analyses of Biological Interaction

MEMBRANE–ACTIVE NATURAL AND SYNTHETIC PEPTIDES AND PEPTIDOMIMETICS

Introduction

Mode of Action of Membrane–Active Peptides

Natural Peptides

Synthetic Peptides

Peptidomimetics

LUMINESCENT QUANTUM DOT FLUORESCENCE RESONANCE ENERGY TRANSFER–BASED PROBES IN CELLULAR AND BIOLOGICAL ASSAYS

Introduction

Luminescent QDs

FRET

QD FRET–Based Protease Probes

NEW PROTEINS FOR NEW SENSING METHODOLOGIES: THE CASE OF THE PROTEIN–BINDING FAMILY

Introduction

Galactose/Glucose–Binding Protein from Escherichia Coli

Glutamine–Binding Protein from E. Coli

Trehalose/Maltose–Binding Protein from the Hyperthermophilic Archaeon Thermococcus Litoralis

Lipocalins and Odorant–Binding Protein

METHODS OF ANALYSIS FOR IMAGING AND DETECTING IONS AND MOLECULES

Fluorescent and Luminescent Proteins

Functional Peptides

Representative Technologies for Molecular Imaging
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Raz Jelinek
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