Chemical Biology - Product Image

Chemical Biology

  • ID: 2179907
  • Book
  • 304 Pages
  • John Wiley and Sons Ltd
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Chemical biology is a rapidly growing and exciting interdisciplinary science, combining chemical tools for the study of biological problems and the development of innovative solutions that would not be possible by applying methodology from one field only.

This first book to adopt a problem–based approach teaches the true basics of the subject by way of illustrated case studies. The editor′s extensive experience in chemical biology education and their close relationship to the authors ensure that the contributions here are presented in a pedagogically uniform and highly motivating fashion.

From the contents:

∗ Ras Proteins, Synthesis, Ras Cycle, Biochemistry

∗ Proteases, Proteasome

∗ Activity–Based Proteomics

∗ FK506

∗ Regulation of Gene Expression, Transcription

∗ Protein Synthesis, Native Chemical Ligation

∗ Expressed Protein Ligation

∗ Microarray Technologies

∗ APT1, Ras Palmitoylation

∗ Carbohydrates

∗ Yeast Based Chemical Genomics

∗ Target Identification

∗ BIOS, PSSC, Natural Products

∗ Alzheimer

∗ Diversity Oriented Synthesis

∗ Kinases, Orthogonal Chemical Genetics

Each chapter introduces a different biological problem, so that students learn how to think in order to solve problems in biology by using powerful techniques and tools taken from chemistry.

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YEAST–BASED CHEMICAL GENOMIC APPROACHES

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation –

Chemogenomic Profiling: Elucidating the Mode of Action of Small Molecules

MIRCOARRAY–BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONS

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

COMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGY

Introduction

Chemical Probes –

A Chemical Question with Biological Consequences

Diversity Oriented Synthesis (DOS)

Biology Oriented Synthesis (BIOS)

TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA–CATENIN PATHWAY MODULATOR

Introduction

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

ACTIVITY–BASED PROTEIN PROFILING OF CYS PROTEASES

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

THE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLID

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

SURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTEREST

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation: ASKA Technology –

Applications in Molecular Biology

MODULATION OF PROTEIN–PROTEIN INTERACTIONS BY SMALL MOLECULES

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

TARGETED PROTEIN DEGRADATION IN LIVE CELLS

Introduction

The Biological Problem

The Chemical Approach

TRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICS

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

NATIVE CHEMIAL LIGATION –

A TOOL FOR CHEMICAL PROTEIN SYNTHESIS

Introduction

The Synthetic Challenge

The Chemical Approach –

Native Chemical Ligation

Chemical Biological Research/Evaluation –

The Ras–RBD Systems

USING SPLIT INTEINS TO PREPARE SEMI–SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS–SPLICING

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

ELUCIDATION OF THE RAS CYCLE WITH SEMI–SYNTHETIC PROTEINS

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

THE STUDY OF RAB GTPASE RECYCLING USING SEMI–SYNTHETIC PRENYLATED PROTEINS

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

DEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPE

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

THE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL–SURFACE GLYCANS

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation

SEQUENCE SPECIFIC DNA–BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTION

Introduction

The Biological Problem –

Targeting DNA with Small Molecules

The Chemical Approach: The Polyamide Rationale

Chemical Biological Research/Evaluation –

Polyamides in Biological Applications

G–QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C–MYC TRANSCRIPTIONAL REGULATION

Introduction

The Biological Problem

The Chemical Approach

Chemical Biological Research/Evaluation
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"This first book to adopt a problem–based approach teaches the true basics of the subject through illustrated everyday case studies. Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to solve problems in biology by using techniques and tools taken from chemistry."

METALL (1/2 2010)

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