Atherosclerosis. Molecular and Cellular Mechanisms

  • ID: 2179951
  • Book
  • 420 Pages
  • John Wiley and Sons Ltd
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With atherosclerosis being the number one cause of death in the western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque.

Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up–to–date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner.

A must–have for master and PhD students, researchers, MDs and lecturers in vascular biology and cardiology, as well as for academics and scientists in the pharmaceutical industry.

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INTRODUCTION

PATHOGENESIS OF ATHEROSCLEROSIS. Sarah George & Cressida Lyon

PROINFLAMMATORY FACTORS

CHEMOKINES AND ATHEROSCLEROSIS: A CRITICAL ASSESSMENT OF THERAPEUTIC TARGETS. Gemma White, Keith Channon & David Greaves

ADHESION MOLECULES AND ATHEROSCLEROSIS Huan Wang & Yuqing Huo

CYTOKINES AND ATHEROSCLEROSIS. Alain Tedgui, Hafid Ait–Oufella and Ziad Mallat

TOLL–LIKE RECEPTORS IN ATHEROSCLEROSIS Zhong–qun Yan, Kristina Edfeldt & Anna Lundberg

PPAR–BASED THERAPIES FOR THE MANAGEMENT OF ATHEROSCLEROSIS Florence Gizard & Inés Pineda–Torra

PENTRAXINS IN VASCULAR PATHOLOGY: THE ROLE OF PTX3. Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi, Fabiola Molla & Roberto Latini

PROTEASES

METALLOPROTEINASES, THE ENDOTHELIUM AND ATHEROSCLEROSIS Stephen White & Andrew Newby

CATHEPSINS IN ATHEROSCLEROSIS Lili Bai, Esther Lutgens & Sylvia Heeneman

THE PLASMIN SYSTEM AND ATHEROSCLEROSIS Chris Jackson & Kevin Carson

MAST CELL PROTEASES AND ATHEROSCLEROSIS Petri Kovanen

HYPERLIPIDEMIA

MACROPHAGE FOAM CELL FORMATION: THE PATHWAYS TO CHOLESTEROL ENGORGEMENT. Kathryn Moore & Katey Rayner

OXIDATIVE STRESS

NADPH OXIDASE AND ATHEROSCLEROSIS Jamie Jeremy, Saima Muzaffar, Carina Mill & Nilima Shukla

UNCOUPLING OF ENDOTHELIAL NITRIC OXIDE SYNTHASE IN ATHEROSCLEROSIS. Colin Cunnington & Keith Channon

HEME OXYGENASE–1 AND ATHEROSCLEROSIS Justin Mason & Faisal Ali

CELL GROWTH AND PHENOTYPE

PHENOTYPIC HETEROGENEITY OF SMOOTH MUSCLE CELLS. IMPLICATIONS FOR ATHEROSCLEROSIS Marie–Matteo Coen and Luce Bochaton–Piallat

PLATELETS: THEIR ROLE IN ATHEROGENESIS AND THROMBOSIS IN CORONARY ARTERY DISEASE. Matthew Harper, Lucy MacCarthy–Morrogh, Matthew Jones, Olga Konopatskaya & Alastair Poole

MODULATORS OF MONOCYTE AND MACROPHAGE PHENOTYPES IN ATHEROSCLEROSIS Nick Jenkins & Jason Johnson

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Sarah Jane George
Jason Johnson
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