Ideas in Chemistry and Molecular Sciences

  • ID: 2179980
  • Book
  • 1272 Pages
  • John Wiley and Sons Ltd
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This volume represents one of the three edited by inviting a selection of young researchers participating to the European Young Chemist Award 2008. The other two volumes concern the two different areas of Synthetic Chemistry and Nanotechnology/Material Science and are respectively entitled "Ideas in Chemistry and Molecular Sciences: Advances in Synthetic Chemistry" and "Ideas in Molecular Sciences: Advances in Nanotechnology, Materials and Devices".

This book contains the contributions of selected young chemists from the field of life sciences. The contributions are grouped under the following umbrella topics:

∗ Biochemical studies

∗ Drug delivery

∗ Research in therapeutics

∗ Enzyme chemistry

∗ Structure–property relationship and biosensing

This volume is an indispensable read for all Biochemists, Molecular Biologists, Organic Chemists, Pharmaceutical Chemists, Medicinal Chemists interested in seeing what tomorrow′s chemistry will look like.
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Preface

PART I: Biochemical Studies

THE ROLE OF COPPER ION AND THE UBIQUITIN SYSTEM IN NEURODEGENERATIVE DISORDERS

Introduction

Metal Ions in the Brain

Brain Copper Homeostasis

Brain Copper and Neurodegenerative Disorders

The Role ob Ubiquitin in Protein Degradation

Failure of the Ubiquitin System in Neurodegenerative Disorders

Interaction of Ubiquitin with Metal Ions

Biological Implications

Conclusions and Perspectives

THE BIOINORGANIC AND ORGANOMETALLIC CHEMISTRY OF COPPER(III)

Introduction

Bioinorganic Implications of Copper(III)

Organometallic CuIII Species in Organic Transformations

Miscellany: Cuprate Superconducting Materials

Overview and Future Targets

CHEMICAL PROTEIN MODIFICATION

Introducing Diversity by Posttranslational Modification

Chemistry: A Route to Modified Proteins

Challenges in Chemical Protein Modification

Traditional Methods for Protein Modification

Recent Innovations in Site–Selective Protein Modification

Conclusion and Outlook

PART II: Drug Delivery

VITAMIN B12: A POTENTIAL TARGETING MOLECULE FOR THERAPEUTIC DRUG DELIVERY

Introduction

Transport Mechanism

Metabolism of B12

Vitamin B12 Derivatives

Outlook

STRATEGIES FOR MICROSPHERE–MEDIATED CELLULAR DELIVERY

Introduction

Microspheres

Future Perspectives

PART III: Research in Therapeutics

FUNDAMENTAL PROCESSES IN RADIATION DAMAGE TO DNA: HOW LOW–ENERGY ELECTRONS DAMAGE BIOMOLECULES

Radiation Damage and the Role of Low–Energy Electrons

DEA Studies on Model Compounds for the DNA Backbone

Outlook and Future Prospects

STRUCTURE–BASED DESIGN ON THE WAY TO NEW ANTI–INFECTIVES

Introduction

Isoprenoids and the Nonmevalonate Pathway

Targeting the CDP–Binding Pocket of IspE

X–Ray Cocrystal Structure Analysis

Conclusions and Outlook

DRUG–MEMBRANE INTERACTIONS: MOLECULAR MECHANISMS UNDERLYING THERAPEUTIC AND TOXIC EFFECTS OF DRUGS

Biological Membranes

Drug–Membrane Interactions

Analysis and Quantification of Drug–Membrane Interactions

Drug–Membrane Interactions Applied to the Study of Nonsteroidal Anti–Inflammatory Drugs (NSAIDs)

Conclusions and Future Research Directions

TARGETING DISEASE WITH SMALL MOLECULE INHIBITORS OF PROTEIN–PROTEIN INTERACTIONS

Introduction

High–Throughput Screening of Chemical Libraries

High–Throughput Screening of Biosynthesized Libraries

Future Direction

CRACKING THE GLYCOCODE: RECENT DEVELOPMENTS IN GLYCOMICS

State of the Art

Some New Insights in Glycomics

Future Perspectives

PART IV: Enzyme Chemistry

O2 REACTIVITY AT MODEL COPPER SYSTEMS: MIMICKING TYROSINASE ACTIVITY

General Introduction: O2 Activation and Model Systems

Copper Proteins Involved in O2 Activation

O2 Binding and Activation at Biomimetic Cu Complexes

Concluding Remarks

PART V: Structure–Property Relationship and Biosensing

CHIRALITY IN BIOCHEMISTRY: A COMPUTATIONAL APPROACH FOR INVESTIGATING BIOMOLECULE CONFORMATIONS

Introduction

Computational Techniques for Studying Protein Dynamics

Employing Chirality to Analyze Protein Motions

Perspectives

COLLISIONAL MECHANISM–BASED E–DNA SENSORS: A GENERAL PLATFORM FOR LABEL–FREE ELECTROCHEMICAL DETECTION OF HYBRIDIZATION AND DNA BINDING PROTEINS

Introduction

E–DNA Signaling Mechanism

E–DNA Sensor for DNA Binding Proteins Detection

Conclusions and Future Perspectives

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Bruno Pignataro
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