Cancer Risk Evaluation. Methods and Trends

  • ID: 2180050
  • Book
  • 366 Pages
  • John Wiley and Sons Ltd
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An overview of the different approaches to cancer risk assessment of environmental factors – including "–omics" technologies, discussing the strengths and weaknesses of the methods in different fields. The main focus is on the carcinogenic effects of ionizing and non–ionizing radiation, demonstrating the difficulties in accurately assessing those factors that may or may not pose a significant cancer risk. The book extends the view to a broader context of risk assessment, highlighting various aspects of risk management. Written by leading experts in the field, this is a resource for policy makers and professionals in health risk assessment, and public health workers, as well as oncologists and researchers in academia.

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Preface

Introduction

MODELS AND APPROACHES

Models of cancer development: genetic and environmental influences (Jandrig)

Endogenous DNA damage and its relevance for the initiation of carcinogenesis (Epe, Fusser)

The IARC Monographs Programme: cancer–hazard identification as a first step in cancer–risk assessment and cancer prevention (Baan, Cogliano)

EPIDEMIOLOGICAL RESEARCH

The role of epidemiology in cancer risk assessment of non–ionising radiation (Schüz, Berg–Beckhoff, Schlehofer, Blettner)

The role of epidemiology in cancer risk assessment of ionizing radiation (Wakeford)

ANIMAL STUDIES

Animal studies on RF–EMF cancer effects (Dasenbrock, Buschmann)

Animal studies in carcinogen identification: The example of power–frequency (50/60 Hz) magnetic fields (McCormick)

GENOTOXICITY STUDIES

Chromosomal aberrations in human populations and cancer (Obe, Lloyd, Durante)

Cytogenetic studies in mammalian somatic cells exposed to radiofrequency radiation: A meta–analysis (Vijayalaxmi , Prihoda)

OMICS –

A NEW TOOL FOR CANCER RISK ASSESSMENT?

Genomics and cancer risk assessment (Schweiger, Timmermann)

Transcriptomics and cancer risk assessment (Kemmner)

Proteomics and cancer risk assessment (Schramm)

CURRENT USE OF OMICS STUDIES FOR CANCER RISK ASSESSMENT

Omics in cancer risk assessment: Pathways to disease (Portier, Thomas)

What have omics taught us about the health risks associated with exposure to low doses of ionizing radiation? (Morgan, Sowa)

Current use of omics studies for cancer risk assessment: Transcriptomics approach in RF–EMF research (Mevissen)

Proteomics approach In mobile phone radiation research (Leszczynski)

CHALLENGES FOR RISK MANAGEMENT

Evaluating the reliability of controversial scientific results (Lerchl)

Comparative risk assessment with ionising and non–ionising radiations (Kiefer)

Communicating about uncertainties in cancer risk assessment (Wiedemann, Schütz)

The Precautionary Principle and radiofrequency exposure from mobile phones (Marchant)

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Overall, the book provides an excellent account of various aspects of cancer and radiation risk assessment for a broad understanding of principles and effects for the betterment of human health.   (Indian J Med Res, 1 March 2013)

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