Preparative Chromatography. 2nd, Completely Revised and Enlarged Edition

  • ID: 2180083
  • Book
  • 566 Pages
  • John Wiley and Sons Ltd
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Completely revised and substantially extended to reflect the developments in this fast–changing field. It retains the interdisciplinary approach

that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes.

It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard

laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is

reflected by new and revised chapters on different modifications of continuous chromatography as well as ion–exchange chromatography and

other separation principles widely used in biochromatography.

Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic

systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes.

Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.
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Preface

INTRODUCTION

On the Development of Chromatography

Focus of the Book

Recommendation to read this Book

FUNDAMENTALS AND GENERAL TERMINOLOGY

Principles of Adsorption Chromatography

Basic Effects and Chromatographic Definitions

Fluid Dynamics

Mass Transfer Phenomena

Equilibrium Thermodynamics

Thermodynamic Effects on Mass Separation

STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS

Column Packings

Selection of Chromatographic Systems

CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION

Introduction

Engineering and Operational Challenges

Chromatography Columns Market

Chromatography Systems Market

Process Control

Packing Methods

Process Troubleshooting

Disposable Technology for Bio–Separations

PROCESS CONCEPTS

Discontinuous Processes

Continuous Processes

Choice of Process Concepts

MODELING AND MODEL PARAMETERS

Introduction

Models for Single Chromatographic Columns

Modeling HPLC plants

Calculations Methods

Parameter Determination

Experimental Validation of Column Models

MODEL BASED DESIGN, OPTIMIZATION AND CONTROL

Basic Principles and Definitions

Batch Chromatography

Recycling Chromatography

Conventional Isocratic SMB Chromatography

Isocratic SMB Chromatography under Variable Operating Parameters

Gradient SMB Chromatography

Multicolumn Systems for Bioseparations

Chromatographic SMB Reactors

Advanced Process Control

APPENDIX B

Data of Test Systems

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"I would not hesitate to recommend it to anyone working in this field."

Chromatographia

"Overall the coverage is a bit uneven – nevertheless the volume does compile some useful material... In conclusion, this is a comprehensive reference text, which should find its way into the libraries of all companies who are serious about process scale preparative chromatography, whether internally or via outsource contracts."

Organic Process Research and Development

"This special volume is essential for chemists and engineers working in chemical and pharmaceutical industries, as well as for food technologies, due to the interdisciplinary nature of these preparative chromatographic processes."

Advances in Food Sciences

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