that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes.
It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard
laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is
reflected by new and revised chapters on different modifications of continuous chromatography as well as ion–exchange chromatography and
other separation principles widely used in biochromatography.
Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic
systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes.
Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.
On the Development of Chromatography
Focus of the Book
Recommendation to read this Book
FUNDAMENTALS AND GENERAL TERMINOLOGY
Principles of Adsorption Chromatography
Basic Effects and Chromatographic Definitions
Mass Transfer Phenomena
Thermodynamic Effects on Mass Separation
STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS
Selection of Chromatographic Systems
CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION
Engineering and Operational Challenges
Chromatography Columns Market
Chromatography Systems Market
Disposable Technology for Bio–Separations
Choice of Process Concepts
MODELING AND MODEL PARAMETERS
Models for Single Chromatographic Columns
Modeling HPLC plants
Experimental Validation of Column Models
MODEL BASED DESIGN, OPTIMIZATION AND CONTROL
Basic Principles and Definitions
Conventional Isocratic SMB Chromatography
Isocratic SMB Chromatography under Variable Operating Parameters
Gradient SMB Chromatography
Multicolumn Systems for Bioseparations
Chromatographic SMB Reactors
Advanced Process Control
Data of Test Systems
"Overall the coverage is a bit uneven – nevertheless the volume does compile some useful material... In conclusion, this is a comprehensive reference text, which should find its way into the libraries of all companies who are serious about process scale preparative chromatography, whether internally or via outsource contracts."
Organic Process Research and Development
"This special volume is essential for chemists and engineers working in chemical and pharmaceutical industries, as well as for food technologies, due to the interdisciplinary nature of these preparative chromatographic processes."
Advances in Food Sciences