Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease s manifestations and current treatment options. Following this introduction, the authors present an in–depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:
- Cardio–Pulmonary Disease
- Infectious Disease
Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.
There are several key associations that can make this book successful. These associations include the American Evaluation Association, the Canadian Evaluation Society, the International Society for Performance Improvement (ISPI), and the Academy of Human Resource Development. Each of these associations includes both practitioners and academics.
1. Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals (Jonathan M. Hill, Ilsa I. Rovira, and Toren Finkel).
2. NF–kB:A Key Signaling Pathway in Asthma (Stewart J. Levine).
3. Molecular Mechanisms of Cancer (Akrit Sodhi, Silvia Montaner, and J. Silvio Gutkind).
4. Apoptotic Pathways in Cancer Progression and Treatment (Joya Chandra and Scott H. Kaufmann).
5. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes (Derek Le Roith, Michael J. Quon, and Yehiel Zick).
6. Dysfunction of G Protein–Regulated Pathways and Endocrine Diseases (William F. Simonds).
7. Bacterial Regulation of the Cytoskeleton (Jeremy W. Peck, Dora C. Stylianou, and Peter D. Burbelo).
8. Bacterial Toxins and Diarrhea (Walter A. Patton, Joel Moss, and Martha Vaughan).
9. Molecular Basis of Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways (Roberta Visconti, Fabio Candotti, and John J. O Shea).
10. Mast Cell–Related Diseases: Genetics, Signaling Pathways, and Novel Therapies (Michael A. Beaven and Thomas R. Hundley).
11. Rheumatology and Signal Transduction (Keith M. Hull and Daniel L. Kastner).
12. Molecular Mechanisms of Neurodegenerative Disorders (Benjamin Wolozin).
13. Neurotrophic Signaling in Mood Disorders (Jing Du,Todd D. Gould, and Husseini K. Manji).
14. Inhibiting Signaling Pathways Through Rational Drug Design (James N.Topper and Neill A. Giese).
"...the overall worth of the book is in the excellent job it does of taking readers from the etiology and management of the disease to our current understanding of the molecular mechanisms involved." (Quarterly Review of Biology, March–May 2005)
a successful work serves as a short summarising overview (Signal Transduction, No.1 2, 2004)
"...appropriate for a textbook...pathways and their regulation are well explained and there are helpful tables and illustrations. The information is current and is well referenced...Finkel, Gutkind, and their coauthors have put together examples that illustrate the growing depth of understanding the roles of signal transduction in disease..." (Cell, January 9, 2004)
...provides a sweeping look at current information derived from assessing the role of some kinases and phosphases on human conditions associated with disease...the book contains thoughtful, well–planned chapters...with extensive citations and excellent artwork...extremely valuable. (Pharmaceutical Research, Vol. 20, No. 12, December 2003)