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An Introduction to Tissue-Biomaterial Interactions. Edition No. 1

  • ID: 2181051
  • Book
  • September 2002
  • 248 Pages
  • John Wiley and Sons Ltd
An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials
  • Proteins
  • Protein-surface interactions
  • Blood-biomaterial interactions
  • Inflammation and infection
  • The immune system
  • Biomaterial responses to implantation
  • Biomaterial surface engineering
  • Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions

The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

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Protein-Surface Interactions.

Blood-Biomaterial Interactions and Coagulation.

Inflammation and Infection.

The Immune System and Inflammation.

Wound Healing.

Biomaterial Surface and the Physiological Environment.


Example 1: Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia.

Example 2: Replacing Joints and Teeth.

Answers to Quiz Questions.


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Kay C. Dee Tulane University Department of Biomedical Engineering, New Orleans, Louisiana.

David A. Puleo University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky.

Rena Bizios Rensselaer Polytechnic Institute, Department of Biomedical Engineering, Troy, New York.
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