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Molecular Basis of Pain Induction

  • ID: 2181099
  • Book
  • 306 Pages
  • John Wiley and Sons Ltd
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The scientific understanding of pain mechanisms has increased dramatically in the last few years, and, in turn, so has the need for a comprehensive volume on the molecular biology of pain and the development of analgesic drugs. Molecular Basis of Pain Induction provides a much–needed reference that covers a broad spectrum of issues while focusing on the molecular aspects of pain and the most recent genetic studies.

This volume reviews the numerous recent advances in the molecular aspects of pain that have aided in the development of analgesic drugs. In such a rapidly growing area of biology, it is essential to thoroughly comprehend how genes involved in pain are identified and whether any new drugs have resulted from pain studies. The development and function of nociceptors is one of the outcomes of these vital molecular genetic studies, and this text reviews the activation of nociceptors by a variety of chemical, thermal, and mechanical stimuli. Some of the other fascinating topics discussed in Molecular Basis of Pain Induction are:

∗ Properties and advances in the study of pain–sensing sensory neurons (nociceptors)

∗ The use of mouse null mutants for the study of problems in genetic background and behavioral research

∗ Insights gained from genetic studies in worms and flies that have aided in the understanding of human sensory neuron function

∗ The detection of noxious mechanical damage

∗ Bradykinin, which evokes pain, and opioid peptides, which block pain

Containing an abundance of useful illustrations and photos to accompany this indispensable text, Molecular Basis of Pain Induction is a resourceful guide for cell and molecular biologists, researchers in pharmaceutical companies, and neuroscientists alike.
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Genetic Approaches to Nociceptor Development (N. Abson, et al.).

Neurotrophic Factor Requirements of Developing Sensory Neurons (A. Davies).

Neurotrophic Signaling and Sensory Neuron Survival and Function (I. Silos–Santiago).

Glial Cell Line–Derived Neurotrophic Factor and Nociceptive Neurons (S. McMahon & D. Bennett).

Molecular Approaches to the Study of Pain (R. Mannion, et al.).

Sensory Neuron–Specific Ion Channels and Receptors (A. Akopian, et al.).

Sensory Neuron Mechanotransduction: Regulation and Underlying Molecular Mechanisms (G. Lewin & C. Stucky).

Role of Bradykinin B—1 and B—2 Receptors in Nociception and Inflammation (N. Rupniak, et al.).

Capsaicin and Vanilloid Receptors (I. James, et al.).

Examination of the Opioid System Using Targeted Gene Deletions (A. Zimmer & T. Usdin).

Role of Substance P in Nociception, Analgesia and Aggression (C. Doyle, et al.).

Molecular Basis of Peripheral Hyperalgesia (S. England).

Sensory Neuronal Cell Lines as Tools for Lineage and Functional Studies (D. Sah).

Index.
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"This welcome and timely book is an excellent starting point for the newcomer to the field of pain research. Readers unfamiliar with the different techniques that can be used to analyze changes in the expression of known candidate genes or to identify and study unknown genes...will find useful guidance."––Trends in Pharmacological Sciences
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