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Head Trauma. Basic, Preclinical, and Clinical Directions

  • ID: 2181110
  • Book
  • 512 Pages
  • John Wiley and Sons Ltd
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Current research on the pathophysiological mechanisms of brain trauma is at the vanguard of neuroscience research. Clinical trials in head trauma are being conducted to determine the potential effectiveness of numerous drugs, with major results projected over the next few years. Unfortunately, no existing book presents the topic of head trauma with both a summary of the science and an extension of these findings into clinical applications. Head Trauma: Basic, Preclinical, and Clinical Directions fills the void in the literature on this subject.

Providing an overview of the major modalities in head trauma therapeutics, this book not only offers a comprehensive presentation of the science in this area but also contains the most up–to–date discussion regarding the basis for experimental and clinical pharmacological treatment of head trauma. Chapters cover basic mechanisms, preclinical targets, clinical aspects with information on efficacy studies, and a straightforward, easy–to–follow presentation of the side effects and potency ratios. In addition, a list of major Web sites of interest and importance to neurotrauma researchers is included.

Additional topics reviewed in Head Trauma: Basic, Preclinical, and Clinical Directions include:

∗ In vitro models of traumatic brain injury

∗ Receptor–based mechanisms in head trauma

∗ Mitochondrial dysfunction following traumatic brain injury

∗ Epidemiology and economics of head trauma

∗ Guidelines for medical and surgical management of head trauma patients used throughout the world

∗ Perspectives on the future of head trauma therapeutics

∗ And much more

With this book, neurosurgeons, neurologists, neurophysiologists, and neuroscientists now have a definitive reference on the subject of head trauma.
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Foreword––Lawrence F. Marshall, MD.




Overview of Basic Mechanisms Underlying Neuropathological Consequences of Head Trauma (P. Lezlinger, et al.).

In Vitro Models of Traumatic Brain Injury (B. Pike).

Contemporary In Vivo Models of Brain Trauma and a Comparison of Injury Responses (A. Kline & C. Dixon).


The Role of Glutamate Receptors in the Pathophysiology of Traumatic Brain Injury (M. Temple, et al.).

Cholinergic Receptors in Head Trauma (B. Lyeth).

Adenosine Receptor Activation in Traumatic Brain Injury (P. Kochanek & L. Miller).

Growth Factors (S. Finklestein & A. Plomaritoglou).

The Inflammatory Response as a Therapeutic Target in Traumatic Brain Injury (P. Kochanek, et al.).

Contribution of Ionic Alterations to Metabolic Dysfunction Following Traumatic Brain Injury (A. Samii, et al.).

Contribution of Calpains and Caspases to Cell Death Following Traumatic Brain Injury (R. Hayes, et al.).

Apoptosis and DNA Damage (R. Raghupathi).

Mitochondrial Dysfunction Following Traumatic Brain Injury (Y. Xiong, et al.).

Traumatic Axonal Injury (J. Povlishock & J. Stone).

Vascular Aspects of Severe Head Injury (M. Zwienenberg & J. Muizelaar).


Epidemiology and Economics of Head Trauma (D. Thurman).

Clinical Presentation and Neuropsychological Sequelae of Traumatic Brain Injury (S. Brown & H. Levin).

The American Brain Injury Consortium (T. Marmarou).

Guidelines for Medical and Surgical Management in Head Trauma Patients in the United States and Europe (D. d′Avella & G. Tomei).

Clinical Trials in Head Injury: United States (P. Muizelaar & L. Miller).

Clinical Trials in Head Injury: Europe (A. Maas).

Clinical Trials in Head Injury: Asia (S. Maejima & Y. Katayama).


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Leonard P. Miller
Ronald L. Hayes
Jennifer K. Newcomb
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