Toxicogenomics. Principles and Applications

  • ID: 2181157
  • Book
  • 362 Pages
  • John Wiley and Sons Ltd
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With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice. This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response of living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application.

Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technologies in genomics, proteomics, metabonomics, and bioinformatics, as well as their applications to toxicology research. Coverage includes:

  • A general introduction to toxicology for nonspecialists
  • Microarray/high–density gene expression profiling
  • Quantitative RNA measurement
  • Analysis of metabolites (metabonomics)
  • Statistics and databases for toxicogenomics
  • Functional genomics models
  • Protein analysis and profiling

Throughout Toxicogenomics, the emphasis remains on information practitioners can put to use immediately. Numerous illustrations support the text, and a helpful summary lists key software and Internet tools, as well as additional resources. Written for specialists and nonspecialists alike, Toxicogenomics gives a wide range of researchers access to the unique combination of disciplines that characterize this exciting new field.

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Contributors.

Foreword.

Preface.

1. General Toxicology (Ronald C Shank).

2. A Short Introduction to the Expression Profile Toolbox, (Jeffrey F. Waring, et al.).

3. Microarray Manufacture (Emile F Nuwaysir).

4. Scanners (Charles J Tucker).

5. Databases for Toxicogenomics (Pierre R Bushel).

6. Statistics for Toxicogenomics (Thomas J Downey Jr).

7. Real–time and Quantitative PCR (Nigel J Walker and Jeanelle Martinez).

8. Toxicogenomics: Confounding Variables and Data Interpretation (Kevin Morgan, et al.).

9. Introduction ito relationships between toxicology and gene expression (Hisham Hamadeh and Robert Dunn).

10. The Use of a Compendium of Expression Profiles for Mechanism of Toxicity Prediction (Jeffrey F Waring, et al.).

11. Using Genetically–Altered Mice in Toxicogenomics Analysis of Chemical Exposure (J Christopher Corton, et al.).

12. Introduction to High–Throughput Prot ein Expression (Alex Merrick).

13. Analytical Proteomics Approaches To Analysis Of Protein Modifications : Tools For Studying Proteome–Environment Interactions (Daniel Liebler).

14. Introduction to Metabolomics and Metabolic Profiling (Robert London and David Houck).

15. Toxicogenomics Resources (Hisham Hamadeh and Rupesh Amin).

Index.

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Hisham K. Hamadeh
Cynthia A. Afshari
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