Handbook of Radiopharmaceuticals. Radiochemistry and Applications

  • ID: 2181221
  • Book
  • 862 Pages
  • John Wiley and Sons Ltd
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The Handbook of Radiopharmaceuticals is an up–to–date, authoritative reference that introduces key issues relating to the production and application of radiopharmaceuticals. The book covers a wide range of radiochemistry and clinical applications including the production of various radionuclides, positron emission tomography (PET) and drug development. Discussions on the uses of radiopharmaceuticals in the diagnosis and therapy of cancer and other diseases are also included.

Features include:

∗ 28 Chapters contributed by world–renowned experts in the field

∗ All aspects of radiopharmaceutical production and applications are discussed

Written by internationally recognised authors, the Handbook of Radiopharmaceuticals is an invaluable resource for advanced graduates and researchers within radiochemistry, analytical and organic chemistry, drug delivery and pharmacokinetics, biochemistry and pharmacology. This book will also be of interest to clinicians, radiologists and radiographers involved in nuclear medicine and radiology. Radiopharmaceuticals are being increasingly utilized as surrogate markers in drug evaluations. This book will be useful to scientists involved in drug development.
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Contributors.

Preface. 

Production of Radionuclides in Accelerators (D. Schlyer).

Accelerators Available for Isotope Production (T. Ruth).

Reactor Production of Radionuclides (L. Mausner and S. Mirzadeh).

Chemistry of  Nitrogen–13 and Oxygen–15  (J. Clark and F. Aigbirhio).

Aspects on the Synthesis of 11C–Labelled Compounds (G. Antoni, et al.). 

Chemistry of Fluorine–18 Radiopharmaceuticals (S. Snyder and M. Kilbourn).

Production and Application of Synthetic Precursors Labeled with Carbon–11 and Fluorine–18 (R. Ferrieri).

Automation for the Synthesis and Application of PET Radiopharmaceuticals (D. Alexoff).

Design and Synthesis of 2–Deoxy–2–[18F]Fluoro–D–Glucose (18FDG) (J. Fowler and T. Ido).

Technetium Radiopharmaceuticals (A. Mahmood and A. Jones).

Chemistry of Gallium and Indium Radiopharmaceuticals (R. Weiner and M. Thakur).

Chemistry of Copper Radionuclides and Radiopharmaceutical Products (C. Anderson, et al.).

Chemistry Applied to Iodine Radionuclides (R. Finn).

Radiobromine for Imaging and Therapy (D. Rowland, et al.).

Development of Radiolabeled Probes to Monitor Gene Therapy (C. Shiue and S. Eck).

Mechanism of Target Specific Uptake Using Examples of Muscarinic Receptor Binding Radiotracers (W. Eckelman).

Strategies for Quantifying PET Imaging Data from Tracer Studies of Brain Receptors and Enzymes (J. Logan).

Radiopharmaceuticals for Studying the Heart (D. Hwang and S. Bergmann).

PET Imaging Studies in Drug Abuse Research (J. Fowler, et al.).

Research and Clinical Application of Neuroreceptor Imaging (H. Wagner and Z. Szabo).

Dynamic Neurotransmitter Interactions Measured with PET (W. Schiffer and S. Dewey).

Tumor Imaging (R. Hustinx and A. Alavi).

Radiolabeled Peptides for Tumor Imaging (L. Knight).

Radiolabeled Antibodies for Tumor Imaging and Therapy (M. Zalutsky and J. Lewis).

Receptor Imaging of Tumors (Non–Peptide) (J. Katzenellenbogen).

Pulmonary Function Imaging with PET Radiopharmaceuticals (P. Elsinga and W. Vaalburg).

Considerations in the Selection of Radionuclides for Cancer Therapy (A. Kassis and S. Adelstein).

Radiopharmaceuticals for the Study of Liver and Renal Function (D. Vera, et al.).

Index.

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"...a must for all colleagues who are involved in radiopharmaceuticals, either at the bench or at the bedside." (Eur Jnl Nuc Med Mol Imaging, August 2003)

"...a unique text that lives up to its goals...a very competent reference for anyone wishing to immerse themselves into the world of radiopharmaceuticals." (The Annals of Phamacotherapy, Vol. 37, November 2003)

"...every aspect of importance in this field is discussed...an excellent overview..." (Eur Jnl Med Mol Imaging, 2003)

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