Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases
Bi–Botti C. Youan
The first standard reference on chronopharmaceutics
As we better understand how biological processes unfold in real time through advances in chronobiology and related fields, we can create safer, more effective drugs, drug delivery systems, and disease monitoring and prevention systems. When administered in correct coordination with a patient′s body rhythms, such drugs can maximize therapeutic outcome while minimizing unwanted side effects. Chronopharmaceutics presents the first standard reference text on this emerging cross–disciplinary field and its potential for therapeutic and preventive medicine.
Bringing together the latest findings from experienced investigators, this edited work presents a much–needed single source on chronopharmaceutics. After an introduction that includes a timeline of key discoveries, an overview of regula–tory, formulation, manufacturing and key resource issues associated with chronopharmaceutics, the detailed coverage examines:
Controlled release systems triggered by physical and/or chemical activation
Chronopharmacodynamics, chronomics, and anesthesia
Filling a gap in both the graduate classroom and the working industrial or research laboratory, Chronopharmaceutics offers students, instructors, and professionals a unique and comprehensive reference for this cutting–edge field.
INTRODUCTION: TIME, DIAGNOSTICS, AND THERAPEUTICS BEYOND CIRCADIAN MARKER RHYTHM–GUIDED TREATMENT (Franz Halberg, Germaine Corne lissen, and Othild Schwartzkopff).
1 OVERVIEW OF CHRONOPHARMACEUTICS (Bi–Botti C. Youan).
2 CHRONOGENETICS (Franck Delaunay).
3 CHRONOPHARMACOKINETICS (Bernard Bruguerolle).
4 CHEMICAL OSCILLATOR SYSTEMS FOR CHRONOTHERAPY (Steven A. Giannos).
5 DIFFUCAPS TECHNOLOGY FOR CONTROLLED RELEASE DRUG DELIVERY (Gopi Venkatesh).
6 CHRONOTOPICt TECHNOLOGY (M. E. Sangalli, A. Maroni, L. Zema, M. Cerea, and A. Gazzaniga).
7 CHRONOTHERAPY USING EGALET TECHNOLOGY (Daniel Bar–Shalom, Clive G. Wilson, and Neena Washington).
8 CHRONSETt: AN OROS DELIVERY SYSTEM FOR CHRONOTHERAPY (Liang C. Dong, Crystal Pollock–Dove, and Patrick S.L. Wong).
9 CONTROLLED RELEASE MICROCHIPS (Karen Daniel, Hong Linh Ho Duc, Michael Cima, and Robert Langer).
10 IMPLICATIONS AND APPLICATIONS OF CIRCADIAN SUSCEPTIBILITY RHYTHMS: CHRONOMICS AND ANESTHESIA (Franz Halberg, Germaine Corne´ lissen, and Othild Schwartzkopff).
11 TREATMENT WITH OPEN EYES: MARKERS–GUIDED CHRONOTHERANOSTICS (Germaine Corne lissen, and Franz Halberg).
Bi–Botti C. Youan, PharmD, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri Kansas City School of Pharmacy. He is on the editorial board of the Journal of Environmental Pollution; and a member of the Controlled Release Society, the American Chemical Society, and the American Association of Pharmaceutical Scientists (AAPS). Dr. Youan initiated the first AAPS Sunrise School on Chronopharmaceutical Drug Delivery in 2004. He earned his doctorate from the Université Catholique de Louvain, Brussels, Belgium.