The major topics covered are stem cell function, including self–renewal, survival, migration, and regulation; the stem cell niche; stem cell fate as lineage commitment takes place; malignant hematopoiesis; hematopoiesis regulators; and embryonic stem cells and plasticity.
As with previous volumes in this unique series of proceedings, it is hoped that further cooperation and collaborative projects will be generated by disseminating these presentations widely.
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Part I: Stem Cell Function:.
1. AMD3100 and CD26 Modulate Mobilization, Engraftment, and Survival of Hematopoietic Stem and Progenitor Cells Mediated by the SDF–1/CXCL12–CXCR4 Axis: Hal E. Broxmeyer, Giao Hangoc, Scott Cooper, Timothy Campbell, Shigeki Ito, and Charlie Mantel.
2. The Stem Cell Continuum: Cell Cycle, Injury, and Phenotype Lability: Peter J. Quesenberry, Gerald Colvin, Gerri Dooner, Mark Dooner, Jason M. Aliotta, and Kevin Johnson.
3. Inference, Validation, and Dynamic Modeling of Transcription Networks in Multipotent Hematopoietic Cells: Shamit Soneji, Sui Huang, Matthew Loose, Ian John Donaldson, Roger Patient, Berthold Gottgens, Tariq Enver, and Gillian May.
Part II: Stem Cell Niche:.
4. Maintenance of Quiescent Hematopoietic Stem Cells in the Osteoblastic Niche: Fumio Arai and Toshio Suda.
5. Cytokine Signaling, Lipid Raft Clustering, and HSC Hibernation: Satoshi Yamazaki, Atsushi Iwama, Yohei Morita, Koji Eto, Hideo Ema, and Hiromitsu Nakauchi.
6. Dormant and Self–Renewing Hematopoietic Stem Cells and Their Niches: Anne Wilson, Gabriela M. Oser, Maike Jaworski, William E. Blanco–Bose, Elisa Laurenti, Christelle Adolphe, Marieke A. Essers, H. Robson MacDonald, and Andreas Trumpp.
Part III: Stem Cell Fate:.
7. Cartography of Hematopoietic Stem Cell Commitment Dependent upon a Reporter for Transcription Factor Activation: Koichi Akashi.
8. Gradients of Antigen Expression and Developmental Potential in Hematopoiesis: Jae–Yong Kwak, Scott Cho, and Gerald J. Spangrude.
9. Biological and Molecular Evidence for Existence of Lymphoid–Primed Multipotent Progenitors: Sidinh Luc, Natalija Buza–Vidas, and Sten Eirik W. Jacobsen.
Part IV: Malignant Hematopoiesis:.
10. Insertional Mutagenesis by Replication–Deficient Retroviral Vectors Encoding the Large T Oncogene: Zhixiong Li, Olga S. Kustikova, Kenji Kamino, Thomas Neumann, Mathias Rhein, Elke Grassman, Boris Fehse, and Christopher Baum.
11. NUP98 Dysregulation in Myeloid Leukemogenesis: M. A. S. Moore, K. Y. Chung, M. Plasilova, J. J. Schuringa, J.–H. Shieh, P. Zhou, and G. Morrone.
Part V: Regulators:.
12. LEF–1 Is a Decisive Transcription Factor in Neutrophil Granulopoiesis: Julia Skokowa and Karl Welte.
13. Role of Thrombopoietin in Mast Cell Differentiation: Anna Rita Migliaccio, Rosa Alba Rana, Alessandro M. Vannucchi, and Francesco A. Manzoli.
14. Thrombopoietic Cells and the Bone Marrow Vascular Niche: H. G. Kopp and S. Rafii.
15. Differential Effects of G Protein Coupled Receptors on Hematopoietic Progenitor Cell Growth Depend on their Signaling Capacities: Xingkui Xue, Zhen Cai, Gabriele Seitz, Lothar Kanz, Katja C. Weisel, and Robert Mohle.
16. Effect of FLT3 Inhibition on Normal Hematopoietic Progenitor Cells: Katja C. Weisel, Sedat Yildirim, Eric Schweikle, Lothar Kanz, and Robert Mohle.
Part VI: Embryonic Stem Cells and Plasticity:.
17. The Cdx–Hox Pathway in Hematopoietic Stem Cell Formation from Embryonic Stem Cells: Claudia Lengerke, Shannon Mckinney–Freeman, Olaia Naveiras, Frank Yates, Yuan Wang, Dimple Bansal, and George Q. Daley.
18. Differentiation Potential of Histocompatible Parthenogenetic Embryonic Stem Cells: Claudia Lengerke, Kitai Kim, Paul Lerou, and George Q. Daley.
19. Hematopoiesis from Human Embryonic Stem Cells: Mickie Bhatia.
20. Emergence of Human Angiohematopoietic Cells in Normal Development and from Cultured Embryonic Stem Cells: Elias T. Zambidis, Lidia Sinka, Manuela Tavian, Venta Jokubaitis, Tea Soon Park, Paul Simmons, and Bruno Peault.
Part VII: Stem Cell Exhaustion:.
21. Epigenetic Control of Hematopoietic Stem Cell Aging: The Case of Ezh2: Gerald De Haan and Alice Gerrits.
22. Telomere Length in Human Natural Killer Cell Subsets: Qin Ouyang, Gabriela Baerlocher, Irma Vulto, and Peter M. Lansdorp.
Part VIII: Mesenchymal Stem Cells and Transplantation:.
23. Flt3 in Regulation of Type I Interferon–Producing Cell and Dendritic Cell.
Development: Nobuyuki Onai, Aya Obata–Onai, Michael A. Schmid, and Markus G. Manz.
24. Novel Markers for the Prospective Isolation of Human MSC: Hans–J Org Buhring, Venkata Lokesh Battula, Sabrina Treml, Bernhard Schewe, Lothar Kanz, and Wichard Vogel.
25. Modulation of Immune Responses by Mesenchymal Stem Cells: Willem E. Fibbe, Alma J. Nauta, and Helene Roelofs.
26. Feasibility and Outcome of Reduced–Intensity Conditioning in Haploidentical Transplantation: Rupert Handgretinger, Xiaohua Chen, Matthias Pfeiffer, Ingo Mueller, Tobias Feuchtinger, Gregory A. Hale, and Peter Lang