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Molecular Biology in Medicinal Chemistry, Volume 21. Methods and Principles in Medicinal Chemistry

  • ID: 2182987
  • Book
  • 435 Pages
  • John Wiley and Sons Ltd
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Molecular Biology and Genetic Engineering have made a great impact on the methods and strategies of modern pharmaceutical and medicinal chemistry, transforming virtually every step in the drug development process, from target finding to drug design and ADMET analysis. Even the synthesis and manufacture of pharmaceutically active compounds has benefited from novel approaches based on molecular biology tools.

From the Contents:

∗ Cellular Assays in Drug Discovery

∗ Transgenic Models

∗ Reporter Gene Assay Systems

∗ Stereoselective Synthesis with Recombinant Enzymes

∗ Nucleic Acid Drugs

∗ Enantioseparation of Chiral Drugs

∗ NMR–based Drug Discovery

∗ Pharmacogenomics and Toxicogenomics

With its broad coverage and up–to–date treatment, this volume is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular biology tools to study drugs and their action.

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MOLECULAR TARGETS

Cellular Assays in Drug Discovery

Gene Knockout Models

Reporter Gene Assay Systems for the Investigation of GPCRs

From the Human Genome to New Drugs: The Potential of Orphan GPCRs

SYNTHESIS

Stereoselective Synthesis with the Help of Recombinant Enzymes

Nucleic Acid Drugs

ANALYSIS

Recent Trends in Enantioseparation of Chiral Drugs

Affinity Chromatography

NMR–based Drug Discovery

13C– and 15N–Isotopic Labeling of Proteins

Antibody Fragments as Crystallization Enhancers

KINETICS, METABOLISM AND TOXICOLOGY

Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response

Pharmacogenomics of Bioavaliability and Elimination

Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology

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Theodor Dingermann
Dieter Steinhilber
Gerd Folkers
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